{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Munk P"],"funding":["EC | Horizon 2020 Framework Programme","Novo Nordisk Fonden"],"pagination":["7251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9715550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transm"],"journal":["Nature communications"],"pubmed_title":["Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance."],"pmcid":["PMC9715550"],"funding_grant_id":["NNF16OC0021856","874735"],"pubmed_authors":["Kiiyukia C","Cuadros-Orellana S","Capone D","Rasolofoarison T","Huete-Pιrez J","Nikiema-Pessinaba SC","Mohammed J","Larsson DGJ","Sopheak T","Bangera SR","Pereckiene A","Elsborg B","de Roda Husman AM","Olivier ZAAJ","van Passel M","Song MJ","Valencia MF","Alebouyeh M","Brinkmann A","Shakenova Z","Corno G","Martinez MC","Baklayan P","Schaeffer J","Sobsey MD","Rodrigues D","Norrgren L","Avsejenko J","Kuroda M","Wester AL","Lefor B","Martins J","Victorien DT","Kurekci C","Leonard A","Yu L","Pathirage S","Cormican M","Diaconu EL","Lopez MG","Samison LH","Tay MYF","Hasan R","Aarestrup FM","Lickes SA","Bandara NKBKRGW","Charlemagne K","Mendoza FP","Rojas MLZ","Alvaro P","Salem MF","Rahube TO","Hisatsune J","Yu Y","Hesse S","Chung T","Kochubovski M","Do Phuc N","Petersen TN","Kalule JB","Tabo DA","Vuthy Y","Vujacic A","Seyfarth AM","Catangcatang K","Alba P","Solymosi N","Wuertz S","Donado-Godoy P","Heikinheimo A","Le Guyader S","Karraouan B","Holmstad R","Daoud Z","Munk P","Hong YP","Fani F","Matar GM","Sanneh B","O'Connor L","Rajandas H","Sukapanpatharam P","Begum A","Boss R","Kwenda G","Davis M","Wasyl D","Gutierrez ADS","Vilchez S","Hendriksen RS","Ivanov I","Mdegela RH","Butrimaite-Ambrozeviciene C","Tran DMN","Coventry K","Bastaraud A","Perera RRDP","Saba CKS","Yoon S","Allerberger F","Beck NK","Graham DW","Sorgaard AM","Orn S","Streikisa M","Tagliati CA","Legesse M","Eguale T","Haber MV","Adisa IR","Levent B","Jergovic M","Collard JM","Yauce FC","Wittum TE","Coulibaly KJ","Djurovic D","Ejobi F","Banda DL","Bunce JT","Zheng H","Van CD","Collignon P","Kotzamanidis C","Chambers ST","Morris D","Di Yoong Wen D","Bartkevics V","Villacis JE","Suthienkul O","Jensen PE","Odetokun IA","Sozzi E","Yost CK","Quintela-Baluja M","Vandenberg O","van Bunnik B","Bouchrif B","Rutgersson C","Moore A","Berglund F","Koopmans M","Hansen LT","Kjeldgaard JS","Oliveira G","Kayama S","Jiao X","Bosevska G","Di Cesare A","Vubil DC","Zhang L","Woolhouse M","Banu RA","Nitsche A","Gustafson NW","Hounmanou YMG","Thomsen J","Lau LT","Deogratias ZN","Manaia C","Adell AD","Feglo PK","Cerda-Cuellar M","Schill CH","Penny C","Oumar T","Esterhuyse K","Chonsin K","Rigamonti N","Soria F","Santchurn SJ","Pastuchova K","Andrianarivelo MR","Ke C","Truong P","Rocha J","Ngandjio A","Jeunen GJ","Thamlikitkul V","Burduniuc O","Trkov M","Fashae K","Thorsteinsdottir TR","Amin A","Ng'eno E","Neilson EHJ","Lytras E","Mohsin M","Obaidi O","Truska P","Cojocaru R","Karpiskova R","Brar SK","Kokina K","Hong PY","Ryrfors P","Bidjada B","Premasiri HI","Cassar S","Gaze WH","Gibb K","Hatha AM","Global Sewage Surveillance Consortium","de Souza LCR","Radosavljevic V","Mazalica N","Gavacova D","Ahmed AO","Perry MR","Gassama A","Pal P","Kocsis B","Ballal M","Parimannan S","Hossain ZZ","Rees C","Magtibay BB","Shakoor S","Kumar P","Schubert S","Koolmeister M","Shin H","Velasquez JE","Hur HG","Brinch C","Van der Heijden T","Morales JFB","Raka L","Kang S","Berzins A","Battisti A","Gemmell N","Bego A","Svendsen CA","Moran-Gilad J","Meschke JS","Jamil K","Spiteri D","Hrenovic J","Lambrinidis D","JiaYong Z","Baisheng L","Power P","Pieters I","Nzouankeu A","Berendonk TU","Keddy K","Jassim LM","Sugai M","Fakhraldeen SA","Lilienthal R","Worrell C","Malania L","Moller FD","Zuniga-Montanez R","Juste BI","Sibulo R","Grujic VR","Abouelnaga M","Njanpop-Lafourcade BM","Alaati T","Schmitt H","Kumburu HH","Brown J","Paredes-Osses E"],"additional_accession":[]},"is_claimable":false,"name":"Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.","description":"Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transm","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T11:51:09.474Z","creation":"2025-04-05T11:51:09.474Z"},"accession":"S-EPMC9715550","cross_references":{"pubmed":["36456547"],"doi":["10.1038/s41467-022-34312-7"]}}