biostudies-literatureWang YNational Natural Science Foundation of ChinaNational Key Research and Development Program of China114701https://www.ebi.ac.uk/biostudies/studies/S-EPMC9715986biostudies-literatureUnknown283<h4>Ethnopharmacological relevance</h4>Xuanfei Baidu Decoction (XFBD), one of the "three medicines and three prescriptions" for the clinically effective treatment of COVID-19 in China, plays an important role in the treatment of mild and/or common patients with dampness-toxin obstructing lung syndrome.<h4>Aim of the study</h4>The present work aims to elucidate the protective effects and the possible mechanism of XFBD against the acute inflammation and pulmonary fibrosis.<h4>Methods</h4>We use TGF-β1 induced fibroblast activation model and LPS/IL-4 induced macrophage inflammation model as in vitro cell models. The mice model of lung fibrosis was induced by BLM via endotracheal drip, and then XFBD (4.6 g/kg, 9.2 g/kg) were administered orally respectively. The efficacy and molecular mechanisJournal of ethnopharmacologyXuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway.PMC97159862020YFA070800082074032Yang JZhu YZhang HXue ZLi LChang YSang XQin HChen XGao XWang YShao RZhang BfalseXuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway.<h4>Ethnopharmacological relevance</h4>Xuanfei Baidu Decoction (XFBD), one of the "three medicines and three prescriptions" for the clinically effective treatment of COVID-19 in China, plays an important role in the treatment of mild and/or common patients with dampness-toxin obstructing lung syndrome.<h4>Aim of the study</h4>The present work aims to elucidate the protective effects and the possible mechanism of XFBD against the acute inflammation and pulmonary fibrosis.<h4>Methods</h4>We use TGF-β1 induced fibroblast activation model and LPS/IL-4 induced macrophage inflammation model as in vitro cell models. The mice model of lung fibrosis was induced by BLM via endotracheal drip, and then XFBD (4.6 g/kg, 9.2 g/kg) were administered orally respectively. The efficacy and molecular mechanis2022-01-01T00:00:00Z2022 Jan2025-04-04T19:49:48.247Z2025-04-04T19:49:48.247ZS-EPMC97159863460694810.1016/j.jep.2021.114701