{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ghasemi A"],"funding":["University of Florida","NIAID NIH HHS","National Institutes of Health"],"pagination":["1034683"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9716130"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<i>Helicobacter pylori</i> is a major cause of gastric mucosal inflammation, peptic ulcers, and gastric cancer. Emerging antimicrobial-resistant <i>H. pylori</i> has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against <i>H. pylori</i>. In this study, we employed a new innovative Protective Immunity Enhanced <i>Salmonella</i> Vaccine (PIESV) vector strain to deliver and express multiple <i>H. pylori</i> antigen genes. Immunization of mice with our vaccine delivering the HpaA, Hp-NAP, UreA and UreB antigens, provided sterile protection against <i>H. pylori</i> SS1 infection in 7 out of 10 tested mice. In comparison to the control groups that had received PBS or a PIESV carrying an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific serum IgG1, IgG2c, total IgG and gastric IgA antibody titers. In conclusion, an improved <i>S.</i> Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against <i>H. pylori</i> infection."],"journal":["Frontiers in immunology"],"pubmed_title":["Protective immunity enhanced <i>Salmonella</i> vaccine vectors delivering <i>Helicobacter pylori</i> antigens reduce <i>H. pylori</i> stomach colonization in mice."],"pmcid":["PMC9716130"],"funding_grant_id":["R01 AI060557","P0109858","R01 AI60557 , R21 AI126172","R21 AI126172"],"pubmed_authors":["Wang S","Sahay B","Abbott JR","Ghasemi A","Curtiss R"],"additional_accession":[]},"is_claimable":false,"name":"Protective immunity enhanced <i>Salmonella</i> vaccine vectors delivering <i>Helicobacter pylori</i> antigens reduce <i>H. pylori</i> stomach colonization in mice.","description":"<i>Helicobacter pylori</i> is a major cause of gastric mucosal inflammation, peptic ulcers, and gastric cancer. Emerging antimicrobial-resistant <i>H. pylori</i> has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against <i>H. pylori</i>. In this study, we employed a new innovative Protective Immunity Enhanced <i>Salmonella</i> Vaccine (PIESV) vector strain to deliver and express multiple <i>H. pylori</i> antigen genes. Immunization of mice with our vaccine delivering the HpaA, Hp-NAP, UreA and UreB antigens, provided sterile protection against <i>H. pylori</i> SS1 infection in 7 out of 10 tested mice. In comparison to the control groups that had received PBS or a PIESV carrying an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific serum IgG1, IgG2c, total IgG and gastric IgA antibody titers. In conclusion, an improved <i>S.</i> Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against <i>H. pylori</i> infection.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-07T13:21:47.222Z","creation":"2025-02-19T04:34:17.566Z"},"accession":"S-EPMC9716130","cross_references":{"pubmed":["36466847"],"doi":["10.3389/fimmu.2022.1034683"]}}