biostudies-literatureRen CEngineering and Physical Sciences Research Council749-764https://www.ebi.ac.uk/biostudies/studies/S-EPMC9716175biostudies-literatureUnknown16(5)Infectious diseases (e.g., coronavirus disease 2019) dramatically impact human life, economy and social development. Exploring the low-cost and energy-saving approaches is essential in removing infectious virus particles from indoors, such as in classrooms. The application of air purification devices, such as negative ion generators (ionizers), gains popularity because of the favorable removal capacity for particles and the low operation cost. However, small and portable ionizers have potential disadvantages in the removal efficiency owing to the limited horizontal diffusion of negative ions. This study aims to investigate the layout strategy (number and location) of ionizers based on the energy-efficient natural ventilation in the classroom to improve removal efficiency (negative ions to Building simulationImpact of ionizers on prevention of airborne infection in classroom.PMC9716175EP/W001411/1Feng ZHaghighat FCao SJKumar PRen CfalseImpact of ionizers on prevention of airborne infection in classroom.Infectious diseases (e.g., coronavirus disease 2019) dramatically impact human life, economy and social development. Exploring the low-cost and energy-saving approaches is essential in removing infectious virus particles from indoors, such as in classrooms. The application of air purification devices, such as negative ion generators (ionizers), gains popularity because of the favorable removal capacity for particles and the low operation cost. However, small and portable ionizers have potential disadvantages in the removal efficiency owing to the limited horizontal diffusion of negative ions. This study aims to investigate the layout strategy (number and location) of ionizers based on the energy-efficient natural ventilation in the classroom to improve removal efficiency (negative ions to 2023-01-01T00:00:00Z20232025-04-18T16:56:36.992Z2025-02-19T04:15:25.571ZS-EPMC97161753647460710.1007/s12273-022-0959-z