biostudies-literatureUnknown5(12)Wisk LE<h4>Importance</h4>Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.<h4>Objective</h4>To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection.<h4>Design, setting, and participants</h4>This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive of SARS-CoV-2 infection at tJAMA network opene2244486https://www.ebi.ac.uk/biostudies/studies/S-EPMC9716377biostudies-literatureAssociation of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness.PMC9716377Huebinger RMPatel AKoo KMontoy JCCSlovis BHChavez SLin ZKane AIdris AHLyon VRuiz LSharma AChan VHunt AWeinstein RAElmore JGUlrich ALi SXPlumb IDMarella PDiaz Roldan KNichol GEguchi MPark JWillis MHill MJGeyer REMcDonald SAChalfin MFernandes AChavez CLHall AJGrau DTMorse DVillegas NShughart HGottlieb MAKemball RMalone KChang AMYu HMiao JWang RCMorse SSchaeffer KWChandler CWMartin KRArab AIHannikainen PWong ASpatz ESHota BBriggs-Hagen MVenkatesh AKStephens KAKelly MO'Laughlin KNRodriguez RKinsman JCheng DWatts PBBlack KStober TKrumholz HDorney JAdams KL'Hommedieu MAnderson JMoreno RLin JSSaydah SShutty CGallegos GDShughart LAINSPIRE GroupSantangelo MWisk LEGentile NLfalseAssociation of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness.<h4>Importance</h4>Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.<h4>Objective</h4>To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection.<h4>Design, setting, and participants</h4>This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive of SARS-CoV-2 infection at t2022-01-01T00:00:00Z2022 Dec2025-04-21T23:23:04.32Z2025-04-05T19:05:45.94ZS-EPMC97163773645457210.1001/jamanetworkopen.2022.44486