biostudies-literatureHuang ZChina Scholarship CouncilGobierno de Arag?n53228-53240https://www.ebi.ac.uk/biostudies/studies/S-EPMC9716523biostudies-literatureUnknown14(47)A variety of two-dimensional (2D) nanomaterials, including graphene oxide and clays, are known to stabilize Pickering emulsions to fabricate structures for functions in sensors, catalysts, and encapsulation. We introduce here a novel Pickering emulsion using self-assembled amphiphilic triblock oligoglycine as the emulsifier. Peptide amphiphiles are more responsive to environmental changes (e.g., pH, temperature, and ionic strength) than inorganic 2D materials, which have a chemically rigid, in-plane structure. Noncovalent forces between the peptide molecules change with the environment, thereby imparting responsiveness. We provide new evidence that the biantennary oligoglycine, Gly₄-NH-C₁₀H₂₀-NH-Gly₄, self-assembles into 2D platelet structures, dACS applied materials & interfacesTwo-Dimensional Triblock Peptide Assemblies for the Stabilization of Pickering Emulsions with pH Responsiveness.PMC9716523201906950049E25_20RKeddie JLJurewicz IHuang ZCalicchia EPortale GGarriga RHowlin BJMunoz EfalseTwo-Dimensional Triblock Peptide Assemblies for the Stabilization of Pickering Emulsions with pH Responsiveness.A variety of two-dimensional (2D) nanomaterials, including graphene oxide and clays, are known to stabilize Pickering emulsions to fabricate structures for functions in sensors, catalysts, and encapsulation. We introduce here a novel Pickering emulsion using self-assembled amphiphilic triblock oligoglycine as the emulsifier. Peptide amphiphiles are more responsive to environmental changes (e.g., pH, temperature, and ionic strength) than inorganic 2D materials, which have a chemically rigid, in-plane structure. Noncovalent forces between the peptide molecules change with the environment, thereby imparting responsiveness. We provide new evidence that the biantennary oligoglycine, Gly₄-NH-C₁₀H₂₀-NH-Gly₄, self-assembles into 2D platelet structures, d2022-01-01T00:00:00Z2022 Nov2025-04-04T07:48:07.612Z2025-04-04T07:48:07.612ZS-EPMC97165233637899310.1021/acsami.2c17558