biostudies-literatureUnknown21Chanthira Kumar HCancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. <i>Morinda citrifolia</i> L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of <i>M. citrifolia</i> using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that <i>M. citrifolia</i> demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. <i>M. citrifolia</i> is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of <i>M. citriflolia</i> in cancer treatment.Integrative cancer therapies15347354221132848https://www.ebi.ac.uk/biostudies/studies/S-EPMC9716600biostudies-literatureEfficacy and Safety of <i>Morinda citrifolia</i> L. (Noni) as a Potential Anticancer Agent.PMC9716600Chanthira Kumar HChin Tan TYMohammad Shafie NLim XYSuhaimi SNMohkiar FHfalseEfficacy and Safety of <i>Morinda citrifolia</i> L. (Noni) as a Potential Anticancer Agent.Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. <i>Morinda citrifolia</i> L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of <i>M. citrifolia</i> using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that <i>M. citrifolia</i> demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. <i>M. citrifolia</i> is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of <i>M. citriflolia</i> in cancer treatment.2022-01-01T00:00:00Z2022 Jan-Dec2025-04-19T04:42:14.653Z2025-04-19T04:42:14.653ZS-EPMC97166003644867410.1177/15347354221132848