{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Wang D"],"pubmed_abstract":["<b>Aims:</b> Inflammatory biomarkers may play vital roles in the pathophysiology of diabetes and diabetic cardiorenal complications. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have a potential cardiovascular and renal protective effect in type 2 diabetes. The aim of this meta-analysis was to quantify the effects of SGLT2 inhibitors on biomarkers of inflammation in randomized controlled trials (RCTs). <b>Methods:</b> PubMed, Cochrane Library, EMBASE, and Web of Science were searched for eligible RCTs of adults with type 2 diabetes (T2D) with no time limit (updated to 12 October 2022). The biomarkers selected included C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, leptin, adiponectin, ferritin, plasminogen activator inhibitor (PAI)-1, and vascular cell adhesion molecule-1. Data were analyzed using a random-effect model in Review Manager 5.4. <b>Results:</b> Thirty-four studies with 6,261 patients (68.6% male) were eligible for this meta-analysis. The mean age of the participants was 62.57(±11.13) years old, and the median treatment duration length with follow-up was 24 weeks. Generally, the included trials were of good methodological quality. The meta-analysis revealed that ferritin levels were significantly reduced in SGLT2 inhibitor treatment groups <i>versus</i> placebo or standard diabetes therapies (SMD: -1.21; 95% CI: -1.91, -0.52, <i>p</i> < 0.001). The effects of CRP (SMD: 0.25; 95% CI: -0.47, -0.03, <i>p</i> = 0.02) and leptin (SMD: -0.22; 95% CI: -0.43, -0.01, <i>p</i> = 0.04) were reduced, and the effects of adiponectin were improved (SMD: 0.28; 95% CI: 0.15, 0.41, <i>p</i> < 0.001) in placebo-controlled studies. PAI-1 levels were significantly reduced in studies controlled for diabetes therapies (SMD: -0.38; 95% CI: -0.61, -0.15, <i>p</i> = 0.001). <b>Conclusion:</b> This analysis provides strong evidence supporting anti-inflammatory effects of SGLT2 inhibitors in T2D subjects. The mechanisms and possible targets for the inflammation reducing and cardiorenal protective properties of SGLT2 inhibitors remain to be explored."],"journal":["Frontiers in pharmacology"],"pagination":["1045235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9717685"],"repository":["biostudies-literature"],"pubmed_title":["The effect of sodium-glucose cotransporter 2 inhibitors on biomarkers of inflammation: A systematic review and meta-analysis of randomized controlled trials."],"pmcid":["PMC9717685"],"pubmed_authors":["Zhou L","Liu J","Li S","Wang D","Xiao X","Zhong L","Zhang Q","Li M"],"additional_accession":[]},"is_claimable":false,"name":"The effect of sodium-glucose cotransporter 2 inhibitors on biomarkers of inflammation: A systematic review and meta-analysis of randomized controlled trials.","description":"<b>Aims:</b> Inflammatory biomarkers may play vital roles in the pathophysiology of diabetes and diabetic cardiorenal complications. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have a potential cardiovascular and renal protective effect in type 2 diabetes. The aim of this meta-analysis was to quantify the effects of SGLT2 inhibitors on biomarkers of inflammation in randomized controlled trials (RCTs). <b>Methods:</b> PubMed, Cochrane Library, EMBASE, and Web of Science were searched for eligible RCTs of adults with type 2 diabetes (T2D) with no time limit (updated to 12 October 2022). The biomarkers selected included C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, leptin, adiponectin, ferritin, plasminogen activator inhibitor (PAI)-1, and vascular cell adhesion molecule-1. Data were analyzed using a random-effect model in Review Manager 5.4. <b>Results:</b> Thirty-four studies with 6,261 patients (68.6% male) were eligible for this meta-analysis. The mean age of the participants was 62.57(±11.13) years old, and the median treatment duration length with follow-up was 24 weeks. Generally, the included trials were of good methodological quality. The meta-analysis revealed that ferritin levels were significantly reduced in SGLT2 inhibitor treatment groups <i>versus</i> placebo or standard diabetes therapies (SMD: -1.21; 95% CI: -1.91, -0.52, <i>p</i> < 0.001). The effects of CRP (SMD: 0.25; 95% CI: -0.47, -0.03, <i>p</i> = 0.02) and leptin (SMD: -0.22; 95% CI: -0.43, -0.01, <i>p</i> = 0.04) were reduced, and the effects of adiponectin were improved (SMD: 0.28; 95% CI: 0.15, 0.41, <i>p</i> < 0.001) in placebo-controlled studies. PAI-1 levels were significantly reduced in studies controlled for diabetes therapies (SMD: -0.38; 95% CI: -0.61, -0.15, <i>p</i> = 0.001). <b>Conclusion:</b> This analysis provides strong evidence supporting anti-inflammatory effects of SGLT2 inhibitors in T2D subjects. The mechanisms and possible targets for the inflammation reducing and cardiorenal protective properties of SGLT2 inhibitors remain to be explored.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T10:34:26.819Z","creation":"2025-02-19T04:34:07.508Z"},"accession":"S-EPMC9717685","cross_references":{"pubmed":["36467062"],"doi":["10.3389/fphar.2022.1045235"]}}