biostudies-literatureUnknown2(4)Cronstrom AAlfred Österlunds StiftelseCrafoordska StiftelsenReumatikerförbundetMedicinska Fakulteten, Lunds UniversitetMagnus Bergvalls StiftelseGreta och Johan Kocks stiftelser<h4>Introduction</h4>Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior cruciate ligament reconstruction (ACLR) is not clear.<h4>Methods and analysis</h4>In this prospective cohort study, 100 patients (50% women, 18-35 years) with ACLR will be recruited from Skåne University Hospital, Sweden and Oslo University Hospital, Norway. They will be assessed with a comprehensive test battery of muscle function including muscle strength, muscle activation, hop performaOsteoarthritis and cartilage open100102https://www.ebi.ac.uk/biostudies/studies/S-EPMC9718207biostudies-literatureIs good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? The SHIELD cohort study protocol.PMC9718207Risberg MASvensson JStruglics AAgeberg EMansson SCronstrom APeterson PTiderius CJOnnerfjord PEnglund MfalseIs good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? The SHIELD cohort study protocol.<h4>Introduction</h4>Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior cruciate ligament reconstruction (ACLR) is not clear.<h4>Methods and analysis</h4>In this prospective cohort study, 100 patients (50% women, 18-35 years) with ACLR will be recruited from Skåne University Hospital, Sweden and Oslo University Hospital, Norway. They will be assessed with a comprehensive test battery of muscle function including muscle strength, muscle activation, hop performa2020-01-01T00:00:00Z2020 Dec2025-06-01T02:06:36.232Z2024-11-14T23:20:05.373ZS-EPMC97182073647487110.1016/j.ocarto.2020.100102