{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sugrue E"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["e1010973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9718408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(11)"],"pubmed_abstract":["HIV-1 transmission via sexual exposure is an inefficient process. When transmission does occur, newly infected individuals are colonized by the descendants of either a single virion or a very small number of establishing virions. These transmitted founder (TF) viruses are more interferon (IFN)-resistant than chronic control (CC) viruses present 6 months after transmission. To identify the specific molecular defences that make CC viruses more susceptible to the IFN-induced 'antiviral state', we established a single pair of fluorescent TF and CC viruses and used arrayed interferon-stimulated gene (ISG) expression screening to identify candidate antiviral effectors. However, we observed a relatively uniform ISG resistance of transmitted HIV-1, and this directed us to investigate possible unde"],"journal":["PLoS pathogens"],"pubmed_title":["The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness."],"pmcid":["PMC9718408"],"funding_grant_id":["MR/V01157X/1","201366/Z/16/Z","MC_UU_12014/10","MC_UU_12018/12","MC_UU_12014/12","MR/P022642/1"],"pubmed_authors":["da Silva Filipe A","Wickenhagen A","Wilson SJ","Tong L","Mollentze N","Sugrue E","Aziz MA","Robertson DL","Hughes J","Rihn SJ","Sreenu VB","Truxa S"],"additional_accession":[]},"is_claimable":false,"name":"The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.","description":"HIV-1 transmission via sexual exposure is an inefficient process. When transmission does occur, newly infected individuals are colonized by the descendants of either a single virion or a very small number of establishing virions. These transmitted founder (TF) viruses are more interferon (IFN)-resistant than chronic control (CC) viruses present 6 months after transmission. To identify the specific molecular defences that make CC viruses more susceptible to the IFN-induced 'antiviral state', we established a single pair of fluorescent TF and CC viruses and used arrayed interferon-stimulated gene (ISG) expression screening to identify candidate antiviral effectors. However, we observed a relatively uniform ISG resistance of transmitted HIV-1, and this directed us to investigate possible unde","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T06:50:03.657Z","creation":"2025-02-19T04:20:28.536Z"},"accession":"S-EPMC9718408","cross_references":{"pubmed":["36399512"],"doi":["10.1371/journal.ppat.1010973"]}}