{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Huang J"],"pubmed_abstract":["<h4>Objective</h4>Thyroid-associated ophthalmopathy (TAO) is a disfiguring autoimmune disease, which destroys the structure of orbital tissues and even threatens vision. Metabolic reprograming is critical in autoimmune diseases; however, the metabolic basis of TAO remains to be clarified. Our study aimed to reveal the metabolic profile of TAO.<h4>Methods</h4>Orbital adipose/connective tissues from eleven TAO patients and twelve control subjects were collected during surgeries and analyzed with liquid chromatograph-mass spectrometer. Orthogonal partial least-squares discrimination analysis (OPLS-DA), variable importance in projection (VIP), heat map, and volcano plot were used to reveal metabolic profile in TAO. Pathway analysis and metabolites-gene analysis were utilized to explore potenti"],"journal":["Frontiers in endocrinology"],"pagination":["1001349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9718489"],"repository":["biostudies-literature"],"pubmed_title":["Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy."],"pmcid":["PMC9718489"],"pubmed_authors":["Wu L","Hu Y","Zhao C","Huang J","Chen M","Liang Y","Zhang Y","Xia W"],"additional_accession":[]},"is_claimable":false,"name":"Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy.","description":"<h4>Objective</h4>Thyroid-associated ophthalmopathy (TAO) is a disfiguring autoimmune disease, which destroys the structure of orbital tissues and even threatens vision. Metabolic reprograming is critical in autoimmune diseases; however, the metabolic basis of TAO remains to be clarified. Our study aimed to reveal the metabolic profile of TAO.<h4>Methods</h4>Orbital adipose/connective tissues from eleven TAO patients and twelve control subjects were collected during surgeries and analyzed with liquid chromatograph-mass spectrometer. Orthogonal partial least-squares discrimination analysis (OPLS-DA), variable importance in projection (VIP), heat map, and volcano plot were used to reveal metabolic profile in TAO. Pathway analysis and metabolites-gene analysis were utilized to explore potenti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-04T09:27:22.515Z","creation":"2025-05-29T16:36:36.188Z"},"accession":"S-EPMC9718489","cross_references":{"pubmed":["36465658"],"doi":["10.3389/fendo.2022.1001349"]}}