{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He P"],"funding":["NHLBI NIH HHS"],"pagination":["7438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9718760"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Complex carbohydrates (glycans) are major players in all organisms due to their structural, energy, and communication roles. This last essential role involves interacting and/or signaling through a plethora of glycan-binding proteins. The design and synthesis of glycans as potential drug candidates that selectively alter or perturb metabolic processes is challenging. Here we describe the first reported sulfur-linked polysaccharides with potentially altered conformational state(s) that are recalcitrant to digestion by heparanase, an enzyme important in human health and disease. An artificial sugar donor with a sulfhydryl functionality is synthesized and enzymatically incorporated into polysaccharide chains utilizing heparosan synthase. Used alone, this donor adds a single thio-sugar onto th"],"journal":["Nature communications"],"pubmed_title":["Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors."],"pmcid":["PMC9718760"],"funding_grant_id":["R01 HL144970"],"pubmed_authors":["Zhang F","Linhardt RJ","Xia K","Pham T","Liu J","Zhang X","Almond A","Green DE","Baytas S","DeAngelis PL","He P","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors.","description":"Complex carbohydrates (glycans) are major players in all organisms due to their structural, energy, and communication roles. This last essential role involves interacting and/or signaling through a plethora of glycan-binding proteins. The design and synthesis of glycans as potential drug candidates that selectively alter or perturb metabolic processes is challenging. Here we describe the first reported sulfur-linked polysaccharides with potentially altered conformational state(s) that are recalcitrant to digestion by heparanase, an enzyme important in human health and disease. An artificial sugar donor with a sulfhydryl functionality is synthesized and enzymatically incorporated into polysaccharide chains utilizing heparosan synthase. Used alone, this donor adds a single thio-sugar onto th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T22:59:59.916Z","creation":"2025-04-19T22:59:59.916Z"},"accession":"S-EPMC9718760","cross_references":{"pubmed":["36460670"],"doi":["10.1038/s41467-022-34788-3"]}}