{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Yuan ZZ"],"pubmed_abstract":["<h4>Background</h4>With the aging of the social population, Osteoarthritis (OA) has already become a vital health and economic problem globally. Shujin Dingtong recipe (SJDTR) is an effective formula to treat OA in China. Although studies have shown that SJDTR can significantly alleviate OA symptoms, its mechanism still remains unclear.<h4>Purpose</h4>This study is aimed at investigating the potential mechanism of SJDTR for the treatment of OA based on network pharmacology and molecular docking.<h4>Methods</h4>Main ingredients of SJDTR were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. OA disease targets were obtained from the Gene Expression Omnibus (GEO) database. The overlapped targets and signaling pathways were explored using Protein-Protein In"],"journal":["Computational and mathematical methods in medicine"],"pagination":["1873004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9719423"],"repository":["biostudies-literature"],"pubmed_title":["A Study on the Potential Mechanism of Shujin Dingtong Recipe against Osteoarthritis Based on Network Pharmacology and Molecular Docking."],"pmcid":["PMC9719423"],"pubmed_authors":["Yang Z","Wu S","Yuan ZZ"],"additional_accession":[]},"is_claimable":false,"name":"A Study on the Potential Mechanism of Shujin Dingtong Recipe against Osteoarthritis Based on Network Pharmacology and Molecular Docking.","description":"<h4>Background</h4>With the aging of the social population, Osteoarthritis (OA) has already become a vital health and economic problem globally. Shujin Dingtong recipe (SJDTR) is an effective formula to treat OA in China. Although studies have shown that SJDTR can significantly alleviate OA symptoms, its mechanism still remains unclear.<h4>Purpose</h4>This study is aimed at investigating the potential mechanism of SJDTR for the treatment of OA based on network pharmacology and molecular docking.<h4>Methods</h4>Main ingredients of SJDTR were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. OA disease targets were obtained from the Gene Expression Omnibus (GEO) database. The overlapped targets and signaling pathways were explored using Protein-Protein In","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-18T03:15:40.606Z","creation":"2025-02-19T04:15:14.41Z"},"accession":"S-EPMC9719423","cross_references":{"pubmed":["36471753"],"doi":["10.1155/2022/1873004"]}}