biostudies-literatureUnknown31Nobrega GM<h4>Objectives</h4>To analyze soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factors (PlGF) concentrations and their ratio in pregnant and postpartum women with suspected COVID-19, and further investigate conditions associated with an increased ratio (sFlt-1/PlGF > 38), including preeclampsia (PE) and severe acute respiratory syndrome (SARS).<h4>Study design</h4>The present study is a secondary analysis of a prospective cohort. Blood samples were collected at time of COVID-19 investigation and the serum measurements of sFlt-1 and PlGF were performed. Clinical background, SARS-CoV-2 infection characteristics, maternal and perinatal outcomes were further analyzed.<h4>Main outcome measures</h4>Serum measurements of sFlt-1 and PlGF; obstetrics and clinical outcomes.<h4>ResultPregnancy hypertension32-37https://www.ebi.ac.uk/biostudies/studies/S-EPMC9719935biostudies-literatureRole of biomarkers (sFlt-1/PlGF) in cases of COVID-19 for distinguishing preeclampsia and guiding clinical management.PMC9719935Lajos GJSouza RTMysorekar IUGuida JPLaura Costa MNovaes JMPietro LLuz AGRibeiro-do-Valle CCNobrega GMDias TZSolda LMCecatti JGfalseRole of biomarkers (sFlt-1/PlGF) in cases of COVID-19 for distinguishing preeclampsia and guiding clinical management.<h4>Objectives</h4>To analyze soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factors (PlGF) concentrations and their ratio in pregnant and postpartum women with suspected COVID-19, and further investigate conditions associated with an increased ratio (sFlt-1/PlGF > 38), including preeclampsia (PE) and severe acute respiratory syndrome (SARS).<h4>Study design</h4>The present study is a secondary analysis of a prospective cohort. Blood samples were collected at time of COVID-19 investigation and the serum measurements of sFlt-1 and PlGF were performed. Clinical background, SARS-CoV-2 infection characteristics, maternal and perinatal outcomes were further analyzed.<h4>Main outcome measures</h4>Serum measurements of sFlt-1 and PlGF; obstetrics and clinical outcomes.<h4>Result2023-01-01T00:00:00Z2023 Mar2026-03-17T16:16:31.972Z2025-02-18T22:54:21.026ZS-EPMC97199353652593310.1016/j.preghy.2022.11.008