{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun X"],"funding":["the 2018 Medical and Health Research Projects in Zhejiang Province"],"pagination":["380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9720910"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Objective</h4>To screen out potential biomarkers by analyzing fundamental nutrients in the bronchoalveolar lavage fluid (BALF) before confirming the lung cancer.<h4>Methods</h4>In this study, 44 patients were enrolled with clinical information. The concentrations of 23 amino acids and 35 carnitines in their BALF were detected with the high-performance liquid chromatography-mass spectrometry (HPLC-MS). Combined with clinicopathological diagnosis, the patients were divided into the lung cancer group (grades I & II and III & IV) and the non-cancer group for standard statistical analysis.<h4>Results</h4>The partial least squares-discriminant analysis (PLS-DA), the Shapiro-Wilk test, and the Bonferroni correction results showed that the serine concentration was higher and the butane-diacyl-carnitine (C4DC) concentration was lower in the lung cancer group, further showing the same changing trend continuously through the non-cancer stage, grades I & II stage and grades III & IV stage. Those two potential biomarkers have been identified.<h4>Conclusion</h4>The HPLC-MS target detection in clinic for nutrient concentration levels is a promising technique to find the changing concentration of serine and C4DC in BALF, which provides an economical and practical way for early warning of lung cancer."],"journal":["World journal of surgical oncology"],"pubmed_title":["The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients."],"pmcid":["PMC9720910"],"funding_grant_id":["2018KY837"],"pubmed_authors":["Xu L","Yang G","Shan Y","Xu M","Zhu Y","Chen X","Sun X","Kong J","Ding L","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.","description":"<h4>Objective</h4>To screen out potential biomarkers by analyzing fundamental nutrients in the bronchoalveolar lavage fluid (BALF) before confirming the lung cancer.<h4>Methods</h4>In this study, 44 patients were enrolled with clinical information. The concentrations of 23 amino acids and 35 carnitines in their BALF were detected with the high-performance liquid chromatography-mass spectrometry (HPLC-MS). Combined with clinicopathological diagnosis, the patients were divided into the lung cancer group (grades I & II and III & IV) and the non-cancer group for standard statistical analysis.<h4>Results</h4>The partial least squares-discriminant analysis (PLS-DA), the Shapiro-Wilk test, and the Bonferroni correction results showed that the serine concentration was higher and the butane-diacyl-carnitine (C4DC) concentration was lower in the lung cancer group, further showing the same changing trend continuously through the non-cancer stage, grades I & II stage and grades III & IV stage. Those two potential biomarkers have been identified.<h4>Conclusion</h4>The HPLC-MS target detection in clinic for nutrient concentration levels is a promising technique to find the changing concentration of serine and C4DC in BALF, which provides an economical and practical way for early warning of lung cancer.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T11:59:44.531Z","creation":"2025-02-19T04:34:08.341Z"},"accession":"S-EPMC9720910","cross_references":{"pubmed":["36464703"],"doi":["10.1186/s12957-022-02850-5"]}}