biostudies-literatureSingal AGNCI NIH HHS1948-1951https://www.ebi.ac.uk/biostudies/studies/S-EPMC9722605biostudies-literatureUnknown117(12)Abdominal ultrasound, with or without alpha-fetoprotein, is the recommended strategy for hepatocellular carcinoma (HCC) surveillance but misses over one-third of HCC at an early stage. Emerging imaging modalities, including computed tomography and magnetic resonance imaging, have early data showing high sensitivity for early-stage HCC, but potential issues such as radiologic capacity, patient acceptance, cost-effectiveness, and need for validation in Western non-hepatitis B virus populations still need to be evaluated. Similarly, blood-based biomarker panels, including GALAD and liquid biopsy techniques, have shown promising data in phase II case-control studies and may concurrently help address issues of surveillance underuse; however, these tools require validation in phase III and IV coThe American journal of gastroenterologyEmerging Tools for Hepatocellular Carcinoma Surveillance.PMC9722605R01 CA222900R01 CA212008U01 CA230694Reig MSingal AGVillanueva AfalseEmerging Tools for Hepatocellular Carcinoma Surveillance.Abdominal ultrasound, with or without alpha-fetoprotein, is the recommended strategy for hepatocellular carcinoma (HCC) surveillance but misses over one-third of HCC at an early stage. Emerging imaging modalities, including computed tomography and magnetic resonance imaging, have early data showing high sensitivity for early-stage HCC, but potential issues such as radiologic capacity, patient acceptance, cost-effectiveness, and need for validation in Western non-hepatitis B virus populations still need to be evaluated. Similarly, blood-based biomarker panels, including GALAD and liquid biopsy techniques, have shown promising data in phase II case-control studies and may concurrently help address issues of surveillance underuse; however, these tools require validation in phase III and IV co2022-01-01T00:00:00Z2022 Dec2025-05-29T21:47:21.249Z2025-05-29T21:47:21.249ZS-EPMC97226053611476810.14309/ajg.0000000000002015