{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["US National Institutes of Health","NCI NIH HHS","National Institutes of Health","National Key Project of Research and Development Program of China"],"pagination":["527-534"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9722635"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8-9)"],"pubmed_abstract":["<h4>Objectives</h4>Population-based prospective studies on the associations of cigarette smoking, alcohol drinking, and primary liver cancer remain limited in Mainland China. Our study was designed to evaluate such relationships in middle-aged Chinese men.<h4>Methods</h4>Self-reported habits of cigarette smoking and alcohol drinking were obtained from all cohort members at the baseline survey. The outcomes were identified through in-person follow-up and annual record linkage to multiple statistics of vital and cancer registration. Age-adjusted and multivariable-adjusted hazard ratio (HR) and their corresponding 95% confidence interval (CI) were estimated utilizing the Cox regression model.<h4>Results</h4>After a median follow-up of 12.31 years, 329 cases of incident primary liver cancer occurred among 45 266 male participants. Compared with never smoker, former smoker was positively associated with liver cancer risk, with a multivariable-adjusted HR of 1.42 (95% CI 1.02-1.98). Individuals who had smoked for more than 40 years had a 49% increased risk of liver cancer (HR<sub>≥40 years</sub>  1.49, 95% CI 1.04-2.14). The association of alcohol drinking with liver cancer showed no statistical significance.<h4>Conclusions</h4>Our study provided evidence that cigarette smoking was positively associated with an increased liver cancer risk among Chinese men. Attention to such non-viral modifiable risk factors to prevent liver cancer effectively is needed."],"journal":["Journal of digestive diseases"],"pubmed_title":["A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men."],"pmcid":["PMC9722635"],"funding_grant_id":["2021YFC2500400","2021YFC2500404","UM1 CA173640"],"pubmed_authors":["Shen QM","Zhang Y","Li HL","Xiang YB","Tan YT","Tuo JY","Li ZY","Tan JY"],"additional_accession":[]},"is_claimable":false,"name":"A prospective cohort study of cigarette smoking, alcohol drinking and liver cancer incidence in Chinese men.","description":"<h4>Objectives</h4>Population-based prospective studies on the associations of cigarette smoking, alcohol drinking, and primary liver cancer remain limited in Mainland China. Our study was designed to evaluate such relationships in middle-aged Chinese men.<h4>Methods</h4>Self-reported habits of cigarette smoking and alcohol drinking were obtained from all cohort members at the baseline survey. The outcomes were identified through in-person follow-up and annual record linkage to multiple statistics of vital and cancer registration. Age-adjusted and multivariable-adjusted hazard ratio (HR) and their corresponding 95% confidence interval (CI) were estimated utilizing the Cox regression model.<h4>Results</h4>After a median follow-up of 12.31 years, 329 cases of incident primary liver cancer occurred among 45 266 male participants. Compared with never smoker, former smoker was positively associated with liver cancer risk, with a multivariable-adjusted HR of 1.42 (95% CI 1.02-1.98). Individuals who had smoked for more than 40 years had a 49% increased risk of liver cancer (HR<sub>≥40 years</sub>  1.49, 95% CI 1.04-2.14). The association of alcohol drinking with liver cancer showed no statistical significance.<h4>Conclusions</h4>Our study provided evidence that cigarette smoking was positively associated with an increased liver cancer risk among Chinese men. Attention to such non-viral modifiable risk factors to prevent liver cancer effectively is needed.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-05-29T16:36:20.488Z","creation":"2025-05-29T16:36:20.488Z"},"accession":"S-EPMC9722635","cross_references":{"pubmed":["36208410"],"doi":["10.1111/1751-2980.13136"]}}