biostudies-literatureUnknown160(2)Mader MMUniversitätsklinikum Hamburg-Eppendorf (UKE)<h4>Introduction</h4>Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures.<h4>Methods</h4>Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retrJournal of neuro-oncology311-320https://www.ebi.ac.uk/biostudies/studies/S-EPMC9722813biostudies-literatureDiffusion tensor imaging changes in patients with glioma-associated seizures.PMC9722813Schmidt NODuhrsen LSedlacik JFaizy TDBorchert PWestphal MMader MMBester MRosengarth KSauvigny TDeuter DfalseDiffusion tensor imaging changes in patients with glioma-associated seizures.<h4>Introduction</h4>Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures.<h4>Methods</h4>Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retr2022-01-01T00:00:00Z2022 Nov2025-04-19T06:18:50.287Z2025-04-19T06:18:50.287ZS-EPMC97228133634485210.1007/s11060-022-04139-9