{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Sibi JM"],"pubmed_abstract":["<h4>Aim</h4>Metabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.<h4>Methods</h4>We quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.<h4>Results</h4>MS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both L"],"journal":["Frontiers in endocrinology"],"pagination":["1011942"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9723321"],"repository":["biostudies-literature"],"pubmed_title":["Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5)."],"pmcid":["PMC9723321"],"pubmed_authors":["Babu S","Sibi JM","Aravindhan V","Deepa M","Mohan V"],"additional_accession":[]},"is_claimable":false,"name":"Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5).","description":"<h4>Aim</h4>Metabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.<h4>Methods</h4>We quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.<h4>Results</h4>MS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both L","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-06-01T02:33:12.931Z","creation":"2024-11-15T06:20:31.046Z"},"accession":"S-EPMC9723321","cross_references":{"pubmed":["36482987"],"doi":["10.3389/fendo.2022.1011942"]}}