biostudies-literatureUnknown13Sibi JM<h4>Aim</h4>Metabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.<h4>Methods</h4>We quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.<h4>Results</h4>MS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both LFrontiers in endocrinology1011942https://www.ebi.ac.uk/biostudies/studies/S-EPMC9723321biostudies-literatureModulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5).PMC9723321Babu SSibi JMAravindhan VDeepa MMohan VfalseModulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5).<h4>Aim</h4>Metabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.<h4>Methods</h4>We quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.<h4>Results</h4>MS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both L2022-01-01T00:00:00Z20222025-06-01T02:33:12.931Z2024-11-15T06:20:31.046ZS-EPMC97233213648298710.3389/fendo.2022.1011942