{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(47)"],"submitter":["van den Boom AFJ"],"funding":["Dutch Research Council (NWO)","Materials innovation institute"],"pubmed_abstract":["SuFEx chemistry has recently evolved as next-generation click chemistry. However, in most SuFEx syntheses, additional reagents/catalysts and carefully controlled conditions are still needed. Here, we aim to further generalize S(VI) exchange chemistry, using 4-nitrophenyl phenylmethanesulfonate as example, in which the nitrophenolate group is exchanged for a wide range of (substituted) phenols and alkyl alcohols. Quantitative yields were reached within 10 min under ambient conditions and required only filtering through silica as workup."],"journal":["Organic letters"],"pagination":["8621-8626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9724081"],"repository":["biostudies-literature"],"pubmed_title":["Sulfur-Phenolate Exchange As a Fluorine-Free Approach to S(VI) Exchange Chemistry on Sulfonyl Moieties."],"pmcid":["PMC9724081"],"pubmed_authors":["van den Boom AFJ","Subramaniam M","Zuilhof H"],"additional_accession":[]},"is_claimable":false,"name":"Sulfur-Phenolate Exchange As a Fluorine-Free Approach to S(VI) Exchange Chemistry on Sulfonyl Moieties.","description":"SuFEx chemistry has recently evolved as next-generation click chemistry. However, in most SuFEx syntheses, additional reagents/catalysts and carefully controlled conditions are still needed. Here, we aim to further generalize S(VI) exchange chemistry, using 4-nitrophenyl phenylmethanesulfonate as example, in which the nitrophenolate group is exchanged for a wide range of (substituted) phenols and alkyl alcohols. Quantitative yields were reached within 10 min under ambient conditions and required only filtering through silica as workup.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T02:16:11.53Z","creation":"2025-04-06T10:25:19.372Z"},"accession":"S-EPMC9724081","cross_references":{"pubmed":["36383144"],"doi":["10.1021/acs.orglett.2c03421"]}}