biostudies-literatureHu CYMinistry of Science and Technology, TaiwanDitmanson Medical Foundation Chia-Yi Christian Hospital104https://www.ebi.ac.uk/biostudies/studies/S-EPMC9724340biostudies-literatureUnknown29(1)<h4>Background</h4>Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (lncRNA), promotes cancer progression in different cancers. Crosstalk between HOTAIR and NF-κB is documented. Prothymosin α (ProT) plays important roles in cancer progression and inflammation. However, the potential link between HOTAIR, ProT, and cisplatin-induced cancer cachexia remains unexplored. Here, we investigated the contribution of HOTAIR in cisplatin-induced cancer cachexia and dissected the potential signaling cascade involving the epidermal growth factor receptor (EGFR), ProT, NF-κB, and HOTAIR.<h4>Materials and methods</h4>Expression of ProT and HOTAIR traJournal of biomedical scienceInterruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer.PMC9724340NCKUCYC-P-11101-2110-2314-B-006-024Shen WTShiau ALShieh GSSu BHChen SYHuang WYHu CYKuo FCFu JTWang CTLee YCYang MLOu CHWu CLTsai YSfalseInterruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer.<h4>Background</h4>Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (lncRNA), promotes cancer progression in different cancers. Crosstalk between HOTAIR and NF-κB is documented. Prothymosin α (ProT) plays important roles in cancer progression and inflammation. However, the potential link between HOTAIR, ProT, and cisplatin-induced cancer cachexia remains unexplored. Here, we investigated the contribution of HOTAIR in cisplatin-induced cancer cachexia and dissected the potential signaling cascade involving the epidermal growth factor receptor (EGFR), ProT, NF-κB, and HOTAIR.<h4>Materials and methods</h4>Expression of ProT and HOTAIR tra2022-01-01T00:00:00Z2022 Dec2025-04-19T06:20:19.768Z2025-04-19T06:20:19.768ZS-EPMC97243403647132910.1186/s12929-022-00887-y