{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["National Natural Science Foundation of China"],"pagination":["336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9724401"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(1)"],"pubmed_abstract":["Background
The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins in human glioblastoma (GBM) are not yet fully understood. In this study, we focused on TRIM56, which emerged as the most differentially expressed TRIM family member with increased expression in GBM.Methods
Western blot, real-time quantitative PCR (qRT-PCR), immunofluorescence (IF) and immunohistochemistry (IHC) were used to study the expression levels of TRIM56 and cIAP1 in GBM cell lines. Co-immunoprecipitation (co-IP) was used to explore the specific binding between target proteins and TRIM56. A xenograft animal model was used to verify the tumor promot"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein."],"pmcid":["PMC9724401"],"funding_grant_id":["81972351","82103277"],"pubmed_authors":["Yang X","Liu X","Li W","Li X","Hu Y","Zhang Y","Han M","Zhou W","Xue Z","Wang J","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein.","description":"Background
The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins in human glioblastoma (GBM) are not yet fully understood. In this study, we focused on TRIM56, which emerged as the most differentially expressed TRIM family member with increased expression in GBM.Methods
Western blot, real-time quantitative PCR (qRT-PCR), immunofluorescence (IF) and immunohistochemistry (IHC) were used to study the expression levels of TRIM56 and cIAP1 in GBM cell lines. Co-immunoprecipitation (co-IP) was used to explore the specific binding between target proteins and TRIM56. A xenograft animal model was used to verify the tumor promot","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T18:54:36.637Z","creation":"2025-04-19T18:54:36.637Z"},"accession":"S-EPMC9724401","cross_references":{"pubmed":["36471347"],"doi":["10.1186/s13046-022-02534-8"]}}