{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(6)"],"submitter":["Nakamura D"],"pubmed_abstract":["<h4>Background</h4>In-stent restenosis (ISR), especially for neoatherosclerosis, is still a major problem of percutaneous coronary intervention (PCI) even in the drug-eluting stent (DES) era.<h4>Aims</h4>The purpose of this study was to investigate the impact of neoatherosclerosis on prognosis after PCI for ISR.<h4>Methods</h4>Between March 2009 and December 2017, 313 ISR lesions in patients undergoing an OCT-guided PCI in five hospitals were retrospectively enrolled. Neoatherosclerosis was defined as a lipid neointima or calcified neointima. We examined the association between neoatherosclerosis and the clinically driven target lesion revascularisation (CD-TLR) rates.<h4>Results</h4>In 313 ISR lesions, 64 lesions (20.4%) had bare metal stents and 241 lesions (77.0%) had drug-eluting stents (DES). Among them, 47.0% of lesions (147 lesions) had neoatherosclerosis. A multivariate logistic regression analysis demonstrated that eGFR (odds ratio [OR] 0.986, 95% confidence interval [CI]: 0.974-0.998; p=0.023), the time from PCI to the ISR (OR 1.13, 95% CI: 1.06-1.22; p<0.001) and DES-ISR (OR 2.48, 95% CI: 1.18-5.43; p=0.019) were independent predictors for neoatherosclerosis. A multivariate regression analysis demonstrated that neoatherosclerosis was an independent predictor of CD-TLR.<h4>Conclusions</h4>In this multicentre ISR registry, OCT imaging demonstrated that eGFR, the time from PCI to the ISR and DES-ISR were independent predictors for neoatherosclerosis and that neoatherosclerosis in ISR lesions had a worse impact on the CD-TLR rate."],"journal":["EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology"],"pagination":["489-496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9725017"],"repository":["biostudies-literature"],"pubmed_title":["Predictors and outcomes of neoatherosclerosis in patients with in-stent restenosis."],"pmcid":["PMC9725017"],"pubmed_authors":["Mizote I","Mano T","Yamada T","Higuchi Y","Nakamura D","Sakata Y","Kikuchi A","Mori N","Nishino M","Dohi T","Yokoi K","Ishihara T","Shiraki T"],"additional_accession":[]},"is_claimable":false,"name":"Predictors and outcomes of neoatherosclerosis in patients with in-stent restenosis.","description":"<h4>Background</h4>In-stent restenosis (ISR), especially for neoatherosclerosis, is still a major problem of percutaneous coronary intervention (PCI) even in the drug-eluting stent (DES) era.<h4>Aims</h4>The purpose of this study was to investigate the impact of neoatherosclerosis on prognosis after PCI for ISR.<h4>Methods</h4>Between March 2009 and December 2017, 313 ISR lesions in patients undergoing an OCT-guided PCI in five hospitals were retrospectively enrolled. Neoatherosclerosis was defined as a lipid neointima or calcified neointima. We examined the association between neoatherosclerosis and the clinically driven target lesion revascularisation (CD-TLR) rates.<h4>Results</h4>In 313 ISR lesions, 64 lesions (20.4%) had bare metal stents and 241 lesions (77.0%) had drug-eluting stents (DES). Among them, 47.0% of lesions (147 lesions) had neoatherosclerosis. A multivariate logistic regression analysis demonstrated that eGFR (odds ratio [OR] 0.986, 95% confidence interval [CI]: 0.974-0.998; p=0.023), the time from PCI to the ISR (OR 1.13, 95% CI: 1.06-1.22; p<0.001) and DES-ISR (OR 2.48, 95% CI: 1.18-5.43; p=0.019) were independent predictors for neoatherosclerosis. A multivariate regression analysis demonstrated that neoatherosclerosis was an independent predictor of CD-TLR.<h4>Conclusions</h4>In this multicentre ISR registry, OCT imaging demonstrated that eGFR, the time from PCI to the ISR and DES-ISR were independent predictors for neoatherosclerosis and that neoatherosclerosis in ISR lesions had a worse impact on the CD-TLR rate.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T11:31:26.647Z","creation":"2025-04-05T11:31:26.647Z"},"accession":"S-EPMC9725017","cross_references":{"pubmed":["32985411"],"doi":["10.4244/EIJ-D-20-00539","10.4244/eij-d-20-00539"]}}