{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li D"],"funding":["Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["e0278688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9725127"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["<h4>Context</h4>Rhizoma drynariae total flavonoids (RDTF) are used to treat fractures. CD31hiEmcnhi vessels induced by PDGF-BB secreted by osteoclast precursors, together with osteoblasts and osteoclasts, constitute the ternary regulatory mechanism of bone tissue reconstruction.<h4>Objective</h4>This study aimed to determine whether RDTF can promote bone tissue remodeling and induce membrane growth in the rat Masquelet model and to explore its molecular mechanism based on the ternary regulation theory.<h4>Methods</h4>Thirty-six SD rats were randomized to three groups: blank, induced membrane, and RDTF treatment (n = 12/group). The gross morphological characteristics of the new bone tissue were observed after 6 weeks. Sixty SD rats were also randomized to five groups: blank, induction membr"],"journal":["PloS one"],"pubmed_title":["Ternary regulation mechanism of Rhizoma drynariae total flavonoids on induced membrane formation and bone remodeling in Masquelet technique."],"pmcid":["PMC9725127"],"funding_grant_id":["No.81603640, No.81974575","No. 20171206"],"pubmed_authors":["Huang F","Jiang Z","Li Y","Li D","Zeng Z","Guan T","Zhao D","Fang B","Xiong H"],"additional_accession":[]},"is_claimable":false,"name":"Ternary regulation mechanism of Rhizoma drynariae total flavonoids on induced membrane formation and bone remodeling in Masquelet technique.","description":"<h4>Context</h4>Rhizoma drynariae total flavonoids (RDTF) are used to treat fractures. CD31hiEmcnhi vessels induced by PDGF-BB secreted by osteoclast precursors, together with osteoblasts and osteoclasts, constitute the ternary regulatory mechanism of bone tissue reconstruction.<h4>Objective</h4>This study aimed to determine whether RDTF can promote bone tissue remodeling and induce membrane growth in the rat Masquelet model and to explore its molecular mechanism based on the ternary regulation theory.<h4>Methods</h4>Thirty-six SD rats were randomized to three groups: blank, induced membrane, and RDTF treatment (n = 12/group). The gross morphological characteristics of the new bone tissue were observed after 6 weeks. Sixty SD rats were also randomized to five groups: blank, induction membr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T22:14:42.51Z","creation":"2025-04-04T22:14:42.51Z"},"accession":"S-EPMC9725127","cross_references":{"pubmed":["36473008"],"doi":["10.1371/journal.pone.0278688"]}}