{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaaban AM"],"funding":["Cancer Research UK"],"pagination":["2125-2132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9726983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["127(12)"],"pubmed_abstract":["<h4>Background</h4>The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial.<h4>Methods</h4>We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012 within the Sloane project.<h4>Results</h4>Microinvasion was recorded in 521 of 11,285 patients (4.6%), with considerable variation in reported incidence among screening units (0-25%). Microinvasion was associated with high-grade DCIS, larger DCIS size, comedo necrosis and solid, cribriform architecture (all P < 0.001). Microinvasion was more frequent in patients who underwent mastectomy compared with breast-conserving surgery (BCS) (6.9% vs 3.6%, P <  0.001), and in those undergoing axillary nodal surgery (60.4% vs 30.3%, P <  0.001) including the subset undergoing BCS (43.4% vs 8.5%, P < 0.001). Nodal metastasis rate was low and not statistically significant difference from the DCIS only group (P = 0.68). Following median follow-up of 110 months, 3% of patients had recurrent ipsilateral high-grade DCIS, and 4.2% developed invasive carcinoma. The subsequent ipsilateral invasion was of Grade 3 in 71.4% of patients with microinvasion vs 30.4% in DCIS without microinvasion (P = 0.02). Distant metastasis and breast cancer mortality were higher with microinvasion compared with DCIS only (1.2% vs 0.3%, P = 0.01 and 2.1% vs 0.8%; P = 0.005).<h4>Conclusions</h4>The higher breast cancer mortality with microinvasion indicates a more aggressive disease."],"journal":["British journal of cancer"],"pubmed_title":["The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)-results from the UK Sloane Project."],"pmcid":["PMC9726983"],"funding_grant_id":["C38317/A24043","PRCRPG-Nov21\\100001","C17422/A25154"],"pubmed_authors":["Sharma N","Litherland J","Provenzano E","Stobart H","Sawyer E","Brace-McDonnell S","Pinder SE","Thompson AM","Mylvaganam S","Dulson-Cox J","Ellis IO","Hilton B","Wallis M","Kearins O","Maxwell A","Clements K","Dodwell D","Kirwan C","Shaaban AM"],"additional_accession":[]},"is_claimable":false,"name":"The presentation, management and outcome of patients with ductal carcinoma in situ (DCIS) with microinvasion (invasion ≤1 mm in size)-results from the UK Sloane Project.","description":"<h4>Background</h4>The diagnosis, management and prognosis of microinvasive breast carcinoma remain controversial.<h4>Methods</h4>We analysed the outcomes of patients with DCIS with and without microinvasion diagnosed between 2003 and 2012 within the Sloane project.<h4>Results</h4>Microinvasion was recorded in 521 of 11,285 patients (4.6%), with considerable variation in reported incidence among screening units (0-25%). Microinvasion was associated with high-grade DCIS, larger DCIS size, comedo necrosis and solid, cribriform architecture (all P < 0.001). Microinvasion was more frequent in patients who underwent mastectomy compared with breast-conserving surgery (BCS) (6.9% vs 3.6%, P <  0.001), and in those undergoing axillary nodal surgery (60.4% vs 30.3%, P <  0.001) including the subset undergoing BCS (43.4% vs 8.5%, P < 0.001). Nodal metastasis rate was low and not statistically significant difference from the DCIS only group (P = 0.68). Following median follow-up of 110 months, 3% of patients had recurrent ipsilateral high-grade DCIS, and 4.2% developed invasive carcinoma. The subsequent ipsilateral invasion was of Grade 3 in 71.4% of patients with microinvasion vs 30.4% in DCIS without microinvasion (P = 0.02). Distant metastasis and breast cancer mortality were higher with microinvasion compared with DCIS only (1.2% vs 0.3%, P = 0.01 and 2.1% vs 0.8%; P = 0.005).<h4>Conclusions</h4>The higher breast cancer mortality with microinvasion indicates a more aggressive disease.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-20T03:19:34.799Z","creation":"2025-04-07T07:01:02.69Z"},"accession":"S-EPMC9726983","cross_references":{"pubmed":["36224403"],"doi":["10.1038/s41416-022-01983-4"]}}