{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Hymel E"],"pubmed_abstract":["<h4>Background</h4>Nonalcoholic fatty liver disease affects about 24% of the world's population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). While more common in those that are obese, NASH-HCC can develop in lean individuals. The mechanisms by which HCC develops and the role of epigenetic changes in the context of obesity and normal weight are not well understood.<h4>Methods</h4>In this study, we used previously generated mouse models of lean and obese HCC using a choline deficient/high trans-fat/fructose/cholesterol diet and a choline supplemented/high trans-fat/fructose/cholesterol diet, respectively, to evaluate methylation differences in HCC progression in lean versus obese mice. Differentially methylated regions were determine"],"journal":["BMC cancer"],"pagination":["1276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9727966"],"repository":["biostudies-literature"],"pubmed_title":["Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma."],"pmcid":["PMC9727966"],"pubmed_authors":["Hymel E","Farazi PA","Fisher KW"],"additional_accession":[]},"is_claimable":false,"name":"Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma.","description":"<h4>Background</h4>Nonalcoholic fatty liver disease affects about 24% of the world's population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). While more common in those that are obese, NASH-HCC can develop in lean individuals. The mechanisms by which HCC develops and the role of epigenetic changes in the context of obesity and normal weight are not well understood.<h4>Methods</h4>In this study, we used previously generated mouse models of lean and obese HCC using a choline deficient/high trans-fat/fructose/cholesterol diet and a choline supplemented/high trans-fat/fructose/cholesterol diet, respectively, to evaluate methylation differences in HCC progression in lean versus obese mice. Differentially methylated regions were determine","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T06:36:21.891Z","creation":"2025-04-19T06:36:21.891Z"},"accession":"S-EPMC9727966","cross_references":{"pubmed":["36474183"],"doi":["10.1186/s12885-022-10389-7"]}}