{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Prinz F"],"funding":["Austrian Science Fund FWF"],"pubmed_abstract":["The microRNA-200 family has wide-ranging regulatory functions in cancer development and progression. Above all, it is strongly associated with the epithelial-to-mesenchymal transition (EMT), a process during which cells change their epithelial to a mesenchymal phenotype and acquire invasive characteristics. More recently, miR-200 family members have also been reported to impact the immune evasion of cancer cells by regulating the expression of immunoinhibitory immune checkpoints (ICs) like PD-L1. Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer. Initial correlation analyses and transient overexpression experiments using miRNA mimics suggested miR-200c-3p as a putative regulato"],"journal":["RNA biology"],"pagination":["1305-1315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9728468"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response."],"pmcid":["PMC9728468"],"pubmed_authors":["Reicher A","Mayr C","Rinner B","Balihodzic A","Pichler M","Kiesslich T","Riedl J","Gerger A","Prinz F","Barth DA","Jonas K","Kargl J","Klec C"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response.","description":"The microRNA-200 family has wide-ranging regulatory functions in cancer development and progression. Above all, it is strongly associated with the epithelial-to-mesenchymal transition (EMT), a process during which cells change their epithelial to a mesenchymal phenotype and acquire invasive characteristics. More recently, miR-200 family members have also been reported to impact the immune evasion of cancer cells by regulating the expression of immunoinhibitory immune checkpoints (ICs) like PD-L1. Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer. Initial correlation analyses and transient overexpression experiments using miRNA mimics suggested miR-200c-3p as a putative regulato","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T11:22:44.012Z","creation":"2025-04-05T23:54:22.241Z"},"accession":"S-EPMC9728468","cross_references":{"pubmed":["36469564"],"doi":["10.1080/15476286.2022.2152978"]}}