{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["NCI NIH HHS"],"pagination":["eadd0005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9728976"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(49)"],"pubmed_abstract":["The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8<sup>+</sup> T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed that <i>IL10RB-DT</i> and <i>LINC01198</i> are significantly correlated with tumor immune response and survival in melanoma and breast cancer. Specifically, <i>IL10RB-DT</i> suppresses CD8<sup>+</sup> T cells activation via inhibiting IFN-γ-JAK-STAT1 signaling and antigen presentation in melanoma and breast cancer cells. On the other hand, <i>LINC01198</i>'s up-regulation sensitizes the killing of tumor cells by CD8<sup>+</sup> T cells. Mechanistically, "],"journal":["Science advances"],"pubmed_title":["Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response."],"pmcid":["PMC9728976"],"funding_grant_id":["R01 CA255196","R01 CA222274","R01 CA233521"],"pubmed_authors":["Pattarayan D","Xie W","Guo W","Bhaskarla C","Zhang M","Yang D","Yadav GS","Zhao Y","Lu B","Li S","Kammula US","Chen Y","Wang X","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response.","description":"The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8<sup>+</sup> T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed that <i>IL10RB-DT</i> and <i>LINC01198</i> are significantly correlated with tumor immune response and survival in melanoma and breast cancer. Specifically, <i>IL10RB-DT</i> suppresses CD8<sup>+</sup> T cells activation via inhibiting IFN-γ-JAK-STAT1 signaling and antigen presentation in melanoma and breast cancer cells. On the other hand, <i>LINC01198</i>'s up-regulation sensitizes the killing of tumor cells by CD8<sup>+</sup> T cells. Mechanistically, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-04T12:27:35.771Z","creation":"2025-02-18T23:25:53.899Z"},"accession":"S-EPMC9728976","cross_references":{"pubmed":["36475797"],"doi":["10.1126/sciadv.add0005"]}}