{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Turecek J"],"funding":["NICHD NIH HHS","NCCIH NIH HHS","NINDS NIH HHS"],"pagination":["310-315"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["612(7939)"],"pubmed_abstract":["The somatosensory system decodes a range of tactile stimuli to generate a coherent sense of touch. Discriminative touch of the body depends on signals conveyed from peripheral mechanoreceptors to the brain through the spinal cord dorsal column and its brainstem target, the dorsal column nuclei (DCN)<sup>1,2</sup>. Models of somatosensation emphasize that fast-conducting low-threshold mechanoreceptors (LTMRs) innervating the skin drive the DCN<sup>3,4</sup>. However, postsynaptic dorsal column (PSDC) neurons within the spinal cord dorsal horn also collect mechanoreceptor signals and form a second major input to the DCN<sup>5-7</sup>. The significance of PSDC neurons and their contributions to the coding of touch have remained unclear since their discovery. Here we show that direct LTMR inpu"],"journal":["Nature"],"pubmed_title":["The encoding of touch by somatotopically aligned dorsal column subdivisions."],"pmcid":["PMC9729103"],"funding_grant_id":["R01 AT011447","R35 NS097344","P50 HD105351"],"pubmed_authors":["Lehnert BP","Turecek J","Ginty DD"],"additional_accession":[]},"is_claimable":false,"name":"The encoding of touch by somatotopically aligned dorsal column subdivisions.","description":"The somatosensory system decodes a range of tactile stimuli to generate a coherent sense of touch. Discriminative touch of the body depends on signals conveyed from peripheral mechanoreceptors to the brain through the spinal cord dorsal column and its brainstem target, the dorsal column nuclei (DCN)<sup>1,2</sup>. Models of somatosensation emphasize that fast-conducting low-threshold mechanoreceptors (LTMRs) innervating the skin drive the DCN<sup>3,4</sup>. However, postsynaptic dorsal column (PSDC) neurons within the spinal cord dorsal horn also collect mechanoreceptor signals and form a second major input to the DCN<sup>5-7</sup>. The significance of PSDC neurons and their contributions to the coding of touch have remained unclear since their discovery. Here we show that direct LTMR inpu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-07-14T15:52:21.567Z","creation":"2025-04-05T12:53:29.454Z"},"accession":"S-EPMC9729103","cross_references":{"pubmed":["36418401"],"doi":["10.1038/s41586-022-05470-x"]}}