biostudies-literatureCross TBreast Cancer Research FoundationSusan G. KomenNew York State Department of Health - Wadsworth CenterU.S. Department of DefenseNational Cancer InstituteNCI NIH HHSRoswell Park Alliance Foundation, Roswell Park Cancer Institute2126-2135https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729381biostudies-literatureUnknown31(12)<h4>Background</h4>Recent evidence suggests that vitamin D might lower breast cancer mortality. There is also growing interest in vitamin D's potential association with health-related quality-of-life (HRQoL). Associations between circulating 25-hydroxyvitamin D (25OHD) concentrations and HRQoL were examined prospectively among breast cancer survivors at the time of diagnosis and 1 year later.<h4>Methods</h4>504 women with incident early-stage breast cancer at Roswell Park Comprehensive Cancer Center were included, and 372 patients provided assessments 1 year later. At each timepoint, participants provided blood samples and completed the SF-36 Health Survey, and surveys on perceived stress, depression, and fatigue. Season-adjusted serum 25OHD concentrations were analyzed in relation to HRQoCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyAssociations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study.PMC9729381P30CA016056P30 CA016056C020918DoD W81XWH0610401BCTR104906O'Connor TLBarone NAttwood KZhang YCross THong CCGeorge AYao SHulme KAmbrosone CBfalseAssociations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study.<h4>Background</h4>Recent evidence suggests that vitamin D might lower breast cancer mortality. There is also growing interest in vitamin D's potential association with health-related quality-of-life (HRQoL). Associations between circulating 25-hydroxyvitamin D (25OHD) concentrations and HRQoL were examined prospectively among breast cancer survivors at the time of diagnosis and 1 year later.<h4>Methods</h4>504 women with incident early-stage breast cancer at Roswell Park Comprehensive Cancer Center were included, and 372 patients provided assessments 1 year later. At each timepoint, participants provided blood samples and completed the SF-36 Health Survey, and surveys on perceived stress, depression, and fatigue. Season-adjusted serum 25OHD concentrations were analyzed in relation to HRQo2022-01-01T00:00:00Z2022 Dec2025-04-26T22:57:44.684Z2025-04-06T17:23:28.442ZS-EPMC97293813612695210.1158/1055-9965.EPI-22-034310.1158/1055-9965.epi-22-0343