biostudies-literatureGutner CANIMH NIH HHSNational Institute of Mental HealthCSRD VA813-823https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729399biostudies-literatureUnknown39(12)<h4>Background</h4>The unified protocol (UP) is a promising transdisgnostic treatment for emotional disorders; limited data exists with trauma-exposed populations. This study compared effectiveness of the UP, presented centered therapy (PCT), and treatment as usual (TAU) in trauma-exposed veterans presenting to routine care.<h4>Method</h4>Trauma-exposed veterans with one or more emotional disorder diagnoses participated in a pilot hybrid-1 effectiveness/preimplementation study. Thirty-seven male and female veterans were randomized to one of three conditions.<h4>Results</h4>Multilevel growth curve modeling demonstrated improvement over time across conditions with large effect sizes (range: -2.15 to -3.32), with the UP demonstrating the greatest change. The between group effect sizes for redDepression and anxietyA pilot randomized effectiveness trial of the unified protocol in trauma-exposed veterans.PMC9729399K23 MH103396I01 CX001422Niles BLGutner CAStirman SWCanale CASong JSuvak MKLitwack SDfalseA pilot randomized effectiveness trial of the unified protocol in trauma-exposed veterans.<h4>Background</h4>The unified protocol (UP) is a promising transdisgnostic treatment for emotional disorders; limited data exists with trauma-exposed populations. This study compared effectiveness of the UP, presented centered therapy (PCT), and treatment as usual (TAU) in trauma-exposed veterans presenting to routine care.<h4>Method</h4>Trauma-exposed veterans with one or more emotional disorder diagnoses participated in a pilot hybrid-1 effectiveness/preimplementation study. Thirty-seven male and female veterans were randomized to one of three conditions.<h4>Results</h4>Multilevel growth curve modeling demonstrated improvement over time across conditions with large effect sizes (range: -2.15 to -3.32), with the UP demonstrating the greatest change. The between group effect sizes for red2022-01-01T00:00:00Z2022 Dec2025-05-29T21:47:18.286Z2025-05-29T21:47:18.286ZS-EPMC97293993625865510.1002/da.23288