biostudies-literatureGelb BDNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Institutes of Health101983https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729438biostudies-literatureUnknown77Precision medicine, defined as tailoring medical care individually based upon relevant factors, is primarily implemented currently through the use of genetic variation. Over the past thirty years, the possibility of determining specific genetic variants underlying congenital heart disease has increased dramatically. This has created the potential for using precision genetic approaches to improve care and outcomes for patients and families with congenital heart disease. In this review, recent advances in understanding the roles of genetic variants in various outcomes, in developing novel therapeutic approaches, and in refining clinical trials for congenital heart disease are discussed.Current opinion in genetics & developmentProspects for precision genetic medicine in congenital heart disease.PMC9729438T32 HL007824U01 HL153009HL153009HL007824R35 HL135742Gelb BDfalseProspects for precision genetic medicine in congenital heart disease.Precision medicine, defined as tailoring medical care individually based upon relevant factors, is primarily implemented currently through the use of genetic variation. Over the past thirty years, the possibility of determining specific genetic variants underlying congenital heart disease has increased dramatically. This has created the potential for using precision genetic approaches to improve care and outcomes for patients and families with congenital heart disease. In this review, recent advances in understanding the roles of genetic variants in various outcomes, in developing novel therapeutic approaches, and in refining clinical trials for congenital heart disease are discussed.2022-01-01T00:00:00Z2022 Dec2025-04-04T09:50:08.137Z2025-02-19T01:17:20.843ZS-EPMC97294383611527610.1016/j.gde.2022.101983