{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laham BJ"],"funding":["NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","NARSAD Young Investigator Award CV STarr Fellow, Princeton University"],"pagination":["7537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729614"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the effects of ELA on adult female mice across the estrous cycle. We found that during diestrus, when progesterone levels are relatively high, ELA mice exhibit increased avoidance behavior and increased theta oscillation power in the ventral hippocampus (vHIP). We also found that diestrus ELA mice had higher levels of progesterone and lower levels of allopregnanolone, a neurosteroid metabolite of progesterone, in the vHIP compared with control-reared mice. Progesterone receptor antagonism normalized avoidance behavior in ELA mice, while treatmen"],"journal":["Nature communications"],"pubmed_title":["The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling."],"pmcid":["PMC9729614"],"funding_grant_id":["R01 MH117459","R01MH117459-01 (EG)"],"pubmed_authors":["Boyer S","Clappier M","Hanani M","Vasquez B","Murthy SS","Gould E","Laham BJ"],"additional_accession":[]},"is_claimable":false,"name":"The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.","description":"Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the effects of ELA on adult female mice across the estrous cycle. We found that during diestrus, when progesterone levels are relatively high, ELA mice exhibit increased avoidance behavior and increased theta oscillation power in the ventral hippocampus (vHIP). We also found that diestrus ELA mice had higher levels of progesterone and lower levels of allopregnanolone, a neurosteroid metabolite of progesterone, in the vHIP compared with control-reared mice. Progesterone receptor antagonism normalized avoidance behavior in ELA mice, while treatmen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-03T21:31:14.165Z","creation":"2025-04-03T21:31:14.165Z"},"accession":"S-EPMC9729614","cross_references":{"pubmed":["36476469"],"doi":["10.1038/s41467-022-35068-w"]}}