biostudies-literaturePereira AFondo Nacional de Desarrollo Científico y TecnológicoFondo de Financiamiento de Centros de Investigación en Áreas Prioritarias21129https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729631biostudies-literatureUnknown12(1)Not all individuals with obesity develop metabolic complications, which has brought about the concepts of metabolically healthy and unhealthy obesity (MHO/MUO). However, inconsistent definitions of these conditions have limited their understanding. We assessed whether a recently-proposed consensus definition for MHO/MUO correlates with adiposity and reflects metabolic risk parameters during puberty. Low-middle income children from the Growth and Obesity Cohort Study (Santiago, Chile) were included (n = 949; 1692 visits at Tanner (T)2, T4 and/or one-year post menarche (1YPM)). Anthropometry, body composition and metabolic parameters were compared between MUO and MHO, and also in children without obesity. The risk for presenting MUO phenotype was significantly elevated with higher waist-heigScientific reportsAssessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages.PMC97296311513001111903461211477Reyes MCorvalan CCifuentes MPereira AEspejo JPMericq VfalseAssessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages.Not all individuals with obesity develop metabolic complications, which has brought about the concepts of metabolically healthy and unhealthy obesity (MHO/MUO). However, inconsistent definitions of these conditions have limited their understanding. We assessed whether a recently-proposed consensus definition for MHO/MUO correlates with adiposity and reflects metabolic risk parameters during puberty. Low-middle income children from the Growth and Obesity Cohort Study (Santiago, Chile) were included (n = 949; 1692 visits at Tanner (T)2, T4 and/or one-year post menarche (1YPM)). Anthropometry, body composition and metabolic parameters were compared between MUO and MHO, and also in children without obesity. The risk for presenting MUO phenotype was significantly elevated with higher waist-heig2022-01-01T00:00:00Z2022 Dec2026-06-03T10:32:12.785Z2024-10-19T13:38:37.493ZS-EPMC97296313647717310.1038/s41598-022-25771-5