{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hess S"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["100820"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9729881"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(11)"],"pubmed_abstract":["Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and rejuvenation, but no organ-level approach is currently available. Using Mycobacterium leprae (ML) with natural partial cellular reprogramming capacity and its animal host nine-banded armadillos, we present an evolutionarily refined model of adult liver growth and regeneration. In infected armadillos, ML reprogram the entire liver and significantly increase total liver/body weight ratio by increasing healthy liver lobules, including hepatocyte proliferation and proportionate expansion of vasculature, and biliary systems. ML-infected livers are microarchitecturally and functionally normal without damage, fibrosis, or tumorigenesis. Bacteria-induced reprogramming reactivates liver progenitor/developmen"],"journal":["Cell reports. Medicine"],"pubmed_title":["In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis."],"pmcid":["PMC9729881"],"funding_grant_id":["MR/P011292/1","095898/Z/11/Z"],"pubmed_authors":["Yamane K","Hess S","Pena M","Adams L","Kendall TJ","Truman R","Soong D","Rambukkana A"],"additional_accession":[]},"is_claimable":false,"name":"In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis.","description":"Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and rejuvenation, but no organ-level approach is currently available. Using Mycobacterium leprae (ML) with natural partial cellular reprogramming capacity and its animal host nine-banded armadillos, we present an evolutionarily refined model of adult liver growth and regeneration. In infected armadillos, ML reprogram the entire liver and significantly increase total liver/body weight ratio by increasing healthy liver lobules, including hepatocyte proliferation and proportionate expansion of vasculature, and biliary systems. ML-infected livers are microarchitecturally and functionally normal without damage, fibrosis, or tumorigenesis. Bacteria-induced reprogramming reactivates liver progenitor/developmen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-07-14T14:26:51.048Z","creation":"2025-04-19T12:14:48.935Z"},"accession":"S-EPMC9729881","cross_references":{"pubmed":["36384103"],"doi":["10.1016/j.xcrm.2022.100820"]}}