{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong YTA"],"funding":["Natural Sciences and Engineering Research Council of Canada","Dutch Research Council (NWO)"],"pagination":["16667-16674"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9730298"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94(48)"],"pubmed_abstract":["The physicochemical properties of active pharmaceutical ingredients (APIs) can depend on their solid-state forms. Therefore, characterization of API forms is crucial for upholding the performance of pharmaceutical products. Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is a powerful technique for API quantification due to its selectivity. However, quantitative SSNMR experiments can be time consuming, sometimes requiring days to perform. Sensitivity can be considerably improved using <sup>1</sup>H SSNMR spectroscopy. Nonetheless, quantification via <sup>1</sup>H can be a challenging task due to low spectral resolution. Here, we offer a novel <sup>1</sup>H SSNMR method for rapid API quantification, termed CRAMPS-MAR. The technique is based on combined rotation and multiple-puls"],"journal":["Analytical chemistry"],"pubmed_title":["Rapid Quantification of Pharmaceuticals via <sup>1</sup>H Solid-State NMR Spectroscopy."],"pmcid":["PMC9730298"],"funding_grant_id":["022.005.029","184.035.002"],"pubmed_authors":["Aspers RLEG","Wong YTA","Uusi-Penttila M","Kentgens APM"],"additional_accession":[]},"is_claimable":false,"name":"Rapid Quantification of Pharmaceuticals via <sup>1</sup>H Solid-State NMR Spectroscopy.","description":"The physicochemical properties of active pharmaceutical ingredients (APIs) can depend on their solid-state forms. Therefore, characterization of API forms is crucial for upholding the performance of pharmaceutical products. Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is a powerful technique for API quantification due to its selectivity. However, quantitative SSNMR experiments can be time consuming, sometimes requiring days to perform. Sensitivity can be considerably improved using <sup>1</sup>H SSNMR spectroscopy. Nonetheless, quantification via <sup>1</sup>H can be a challenging task due to low spectral resolution. Here, we offer a novel <sup>1</sup>H SSNMR method for rapid API quantification, termed CRAMPS-MAR. The technique is based on combined rotation and multiple-puls","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T12:52:50.876Z","creation":"2025-04-05T12:52:50.876Z"},"accession":"S-EPMC9730298","cross_references":{"pubmed":["36417314"],"doi":["10.1021/acs.analchem.2c02905"]}}