{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lindberg I"],"funding":["NIA NIH HHS"],"pagination":["1463-1478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9731515"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["<h4>Background</h4>Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures.<h4>Objective</h4>To determine if proSAAS overexpression is neuroprotective in animal models of Parkinson's disease.<h4>Methods</h4>proSAAS- or GFP-encoding lentivirus was injected together with human aSyn-expressing AAV unilaterally into the substantia nigra of rats and motor asymmetry assessed using a battery of motor performance tests. Dopamine neuron survival was assessed by nigral stereology and striatal tyrosine hydroxylase (TH) densitometry. To examine transsynaptic spread of aSyn, aSyn AAV was injected "],"journal":["Journal of Parkinson's disease"],"pubmed_title":["The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease."],"pmcid":["PMC9731515"],"funding_grant_id":["R01 AG062222"],"pubmed_authors":["Helwig M","Maidment NT","Yucer N","Shu Z","Svendsen CN","Di Monte DA","Lindberg I","Lam H","Laperle A"],"additional_accession":[]},"is_claimable":false,"name":"The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.","description":"<h4>Background</h4>Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures.<h4>Objective</h4>To determine if proSAAS overexpression is neuroprotective in animal models of Parkinson's disease.<h4>Methods</h4>proSAAS- or GFP-encoding lentivirus was injected together with human aSyn-expressing AAV unilaterally into the substantia nigra of rats and motor asymmetry assessed using a battery of motor performance tests. Dopamine neuron survival was assessed by nigral stereology and striatal tyrosine hydroxylase (TH) densitometry. To examine transsynaptic spread of aSyn, aSyn AAV was injected ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T00:35:34.549Z","creation":"2025-04-04T00:35:34.549Z"},"accession":"S-EPMC9731515","cross_references":{"pubmed":["35527562"],"doi":["10.3233/jpd-213053","10.3233/JPD-213053"]}}