{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Mungale A"],"funding":["National Eye Institute"],"pubmed_abstract":["The macula and fovea comprise a highly sensitive visual detection tissue that is susceptible to common disease processes like age-related macular degeneration (AMD). Our understanding of the molecular determinants of high acuity vision remains unclear, as few model organisms possess a human-like fovea. We explore transcription factor networks and receptor-ligand interactions to elucidate tissue interactions in the macula and peripheral retina and concomitant changes in the underlying retinal pigment epithelium (RPE)/choroid. Poly-A selected, 100 bp paired-end RNA-sequencing (RNA-seq) was performed across the macular/foveal, perimacular, and temporal peripheral regions of the neural retina and RPE/choroid tissues of four adult Rhesus macaque eyes to characterize region- and tissue-specific "],"journal":["Frontiers in genetics"],"pagination":["949449"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9732541"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways."],"pmcid":["PMC9732541"],"pubmed_authors":["Liu J","Mungale A","Maminishkis A","Fufa TD","Brooks BP","Hufnagel RB","McGaughey DM","Yousaf S","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways.","description":"The macula and fovea comprise a highly sensitive visual detection tissue that is susceptible to common disease processes like age-related macular degeneration (AMD). Our understanding of the molecular determinants of high acuity vision remains unclear, as few model organisms possess a human-like fovea. We explore transcription factor networks and receptor-ligand interactions to elucidate tissue interactions in the macula and peripheral retina and concomitant changes in the underlying retinal pigment epithelium (RPE)/choroid. Poly-A selected, 100 bp paired-end RNA-sequencing (RNA-seq) was performed across the macular/foveal, perimacular, and temporal peripheral regions of the neural retina and RPE/choroid tissues of four adult Rhesus macaque eyes to characterize region- and tissue-specific ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T15:59:28.829Z","creation":"2025-02-19T04:44:07.748Z"},"accession":"S-EPMC9732541","cross_references":{"pubmed":["36506320"],"doi":["10.3389/fgene.2022.949449"]}}