{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stasi M"],"funding":["H2020 Marie Sklodowska-Curie Actions","European Research Council","Deutsche Forschungsgemeinschaft","Technische Universit?t M?nchen"],"pagination":["21939-21947"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9732876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(48)"],"pubmed_abstract":["Molecular machines, such as ATPases or motor proteins, couple the catalysis of a chemical reaction, most commonly hydrolysis of nucleotide triphosphates, to their conformational change. In essence, they continuously convert a chemical fuel to drive their motion. An outstanding goal of nanotechnology remains to synthesize a nanomachine with similar functions, precision, and speed. The field of DNA nanotechnology has given rise to the engineering precision required for such a device. Simultaneously, the field of systems chemistry developed fast chemical reaction cycles that convert fuel to change the function of molecules. In this work, we thus combined a chemical reaction cycle with the precision of DNA nanotechnology to yield kinetic control over the conformational state of a DNA hairpin. "],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle."],"pmcid":["PMC9732876"],"funding_grant_id":["724261","765703","EXC-2094  411722921","852187","EXC-2094  390783311"],"pubmed_authors":["Babl L","Dirscherl CF","Boekhoven J","Dietz H","Stasi M","Wunnava S","Monferrer A","Schwille P","Braun D"],"additional_accession":[]},"is_claimable":false,"name":"Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle.","description":"Molecular machines, such as ATPases or motor proteins, couple the catalysis of a chemical reaction, most commonly hydrolysis of nucleotide triphosphates, to their conformational change. In essence, they continuously convert a chemical fuel to drive their motion. An outstanding goal of nanotechnology remains to synthesize a nanomachine with similar functions, precision, and speed. The field of DNA nanotechnology has given rise to the engineering precision required for such a device. Simultaneously, the field of systems chemistry developed fast chemical reaction cycles that convert fuel to change the function of molecules. In this work, we thus combined a chemical reaction cycle with the precision of DNA nanotechnology to yield kinetic control over the conformational state of a DNA hairpin. ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-20T03:30:23.992Z","creation":"2025-04-20T03:30:23.992Z"},"accession":"S-EPMC9732876","cross_references":{"pubmed":["36442850"],"doi":["10.1021/jacs.2c08463"]}}