biostudies-literatureZhang XThe Key Scientific Research Project of Colleges and Universities in Henan Province of ChinaRenshu Fund Project of Hunan Provincial People’s HospitalRenshu Fund Project of Hunan Provincial People's HospitalNational Science and Technology Major Project of China under GrantThe Training Program of Henan Provincial Higher Vocational School Young Backbone TeachersThe Science and Technology Project in Henan Province of ChinaThe Joint Construction Project of Henan Medical Science and Technology Research Plan in Henan Province of China393https://www.ebi.ac.uk/biostudies/studies/S-EPMC9733014biostudies-literatureUnknown22(1)<h4>Background</h4>The dysregulation of CD5L has been reported in hepatocellular carcinoma (HCC). However, its functions in HCC were controversial. In this study, we aimed to identify CD5L-associated pathways and markers and explore their values in HCC diagnosis, prognosis and treatment.<h4>Methods</h4>HCC datasets with gene expression profiles and clinical data in TCGA and ICGC were downloaded. The immune/stroma cell infiltrations were estimated with xCell. CD5L-associated pathways and CD5L-associated genes (CD5L-AGs) were identified with gene expression comparisons and gene set enrichment analysis (GSEA). Cox regression, Kaplan-Meier survival analysis, and least absolute shrinkage and selection operator (LASSO) regression analysis were performed. The correlations of the key genes with imCancer cell internationalCD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma.PMC9733014LHGJ2019071720B3200072221023104082020-20RS2018032018ZX10302205Liu XDai LZhang JZhang XZhu KSun TFan SLi NfalseCD5L-associated gene analyses highlight the dysregulations, prognostic effects, immune associations, and drug-sensitivity predicative potentials of LCAT and CDC20 in hepatocellular carcinoma.<h4>Background</h4>The dysregulation of CD5L has been reported in hepatocellular carcinoma (HCC). However, its functions in HCC were controversial. In this study, we aimed to identify CD5L-associated pathways and markers and explore their values in HCC diagnosis, prognosis and treatment.<h4>Methods</h4>HCC datasets with gene expression profiles and clinical data in TCGA and ICGC were downloaded. The immune/stroma cell infiltrations were estimated with xCell. CD5L-associated pathways and CD5L-associated genes (CD5L-AGs) were identified with gene expression comparisons and gene set enrichment analysis (GSEA). Cox regression, Kaplan-Meier survival analysis, and least absolute shrinkage and selection operator (LASSO) regression analysis were performed. The correlations of the key genes with im2022-01-01T00:00:00Z2022 Dec2026-05-29T18:48:09.195Z2024-11-13T21:50:38.903ZS-EPMC97330143649469610.1186/s12935-022-02820-7