{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu L"],"funding":["National Natural Science Foundation of China"],"pagination":["519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9733225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced by TGF-β families. Migrasome is a recently discovered type of extracellular vesicle related to cell migration.<h4>Results</h4>Here, we used ex vivo, in vitro, and in vivo models, to investigate the characteristics and functions of migrasomes in RPE activation and PVR development. Results indicated that the migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed in human PVR-associated clinical samples. The ex vivo model PVR microenvironment is simulated by incubating brown Norway rat RPE eyecups with TGF-β1. Electron microscope images showed the formation of migrasome-like vesicles during the activation of RPE. Furt"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy."],"pmcid":["PMC9733225"],"funding_grant_id":["81770939"],"pubmed_authors":["Li H","Feng L","Wu L","Gu X","Zhang Y","Wang F","Zhang C","Wei J","Yang S","Xu G","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy.","description":"<h4>Background</h4>Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced by TGF-β families. Migrasome is a recently discovered type of extracellular vesicle related to cell migration.<h4>Results</h4>Here, we used ex vivo, in vitro, and in vivo models, to investigate the characteristics and functions of migrasomes in RPE activation and PVR development. Results indicated that the migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed in human PVR-associated clinical samples. The ex vivo model PVR microenvironment is simulated by incubating brown Norway rat RPE eyecups with TGF-β1. Electron microscope images showed the formation of migrasome-like vesicles during the activation of RPE. Furt","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T19:19:10.259Z","creation":"2024-11-12T23:05:58.752Z"},"accession":"S-EPMC9733225","cross_references":{"pubmed":["36494806"],"doi":["10.1186/s12951-022-01732-y"]}}