{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Audouard E"],"funding":["Horizon 2020"],"pagination":["994-1008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9733677"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["352"],"pubmed_abstract":["Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based "],"journal":["Journal of controlled release : official journal of the Controlled Release Society"],"pubmed_title":["Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis."],"pmcid":["PMC9733677"],"funding_grant_id":["720694"],"pubmed_authors":["Buchmann P","Florea M","Khel A","Rousselot L","Escudero E","Audouard E","Dufayet-Chauffaut G","Cartier N","Michel F","Folcher M","Kim T","Piguet F","Pierroz V","Altynbekova K","Delgaldo C","Gillet-Legrand B","Soler ABA"],"additional_accession":[]},"is_claimable":false,"name":"Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis.","description":"Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-28T02:52:07.257Z","creation":"2024-11-12T10:54:55.498Z"},"accession":"S-EPMC9733677","cross_references":{"pubmed":["36370877"],"doi":["10.1016/j.jconrel.2022.11.008"]}}