biostudies-literatureAudouard EHorizon 2020994-1008https://www.ebi.ac.uk/biostudies/studies/S-EPMC9733677biostudies-literatureUnknown352Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based Journal of controlled release : official journal of the Controlled Release SocietyBioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis.PMC9733677720694Buchmann PFlorea MKhel ARousselot LEscudero EAudouard EDufayet-Chauffaut GCartier NMichel FFolcher MKim TPiguet FPierroz VAltynbekova KDelgaldo CGillet-Legrand BSoler ABAfalseBioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis.Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based 2022-01-01T00:00:00Z2022 Dec2026-05-28T02:52:07.257Z2024-11-12T10:54:55.498ZS-EPMC97336773637087710.1016/j.jconrel.2022.11.008