{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["7629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9734111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The ongoing COVID-19 pandemic has demonstrated that viral diseases represent an enormous public health and economic threat to mankind and that individuals with compromised immune systems are at greater risk of complications and death from viral diseases. The development of broad-spectrum antivirals is an important part of pandemic preparedness. Here, we have engineer a series of designer cells which we term autonomous, intelligent, virus-inducible immune-like (ALICE) cells as sense-and-destroy antiviral system. After developing a destabilized STING-based sensor to detect viruses from seven different genera, we have used a synthetic signal transduction system to link viral detection to the expression of multiple antiviral effector molecules, including antiviral cytokines, a CRISPR-Cas9 modu"],"journal":["Nature communications"],"pubmed_title":["Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice."],"pmcid":["PMC9734111"],"funding_grant_id":["31861143016","31971346"],"pubmed_authors":["Zhou P","Zhang H","Kong D","Huang Q","Cai F","Pei R","Liu Y","Tan CW","Xue S","Wang LF","Chia WN","Anderson DE","Deng Z","Wang X","Liu C","Wang Y","Wang Z","Shen X","Ye H","Xu Y","Qiao L"],"additional_accession":[]},"is_claimable":false,"name":"Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice.","description":"The ongoing COVID-19 pandemic has demonstrated that viral diseases represent an enormous public health and economic threat to mankind and that individuals with compromised immune systems are at greater risk of complications and death from viral diseases. The development of broad-spectrum antivirals is an important part of pandemic preparedness. Here, we have engineer a series of designer cells which we term autonomous, intelligent, virus-inducible immune-like (ALICE) cells as sense-and-destroy antiviral system. After developing a destabilized STING-based sensor to detect viruses from seven different genera, we have used a synthetic signal transduction system to link viral detection to the expression of multiple antiviral effector molecules, including antiviral cytokines, a CRISPR-Cas9 modu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-07-14T15:24:34.724Z","creation":"2024-11-13T21:50:21.632Z"},"accession":"S-EPMC9734111","cross_references":{"pubmed":["36494373"],"doi":["10.1038/s41467-022-35425-9"]}}