{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Martin E"],"funding":["FEDER funds","Instituto de Salud Carlos III","Junta de Extremadura, Mérida, Spain","Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Madrid, Spain"],"pagination":["15244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9735634"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(23)"],"pubmed_abstract":["Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between <i>LAG3</i> gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the <i>CD4</i> and <i>LAG3</i> genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> in 300 patients diagnosed with MS and 400 healthy patients using specific <i>TaqMan</i>-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the <i>HLADRB1*1501</i> genotype. The frequencies of the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and <i>HLADRB1*1501</i> genotype. The results of the current study showed a lack of association between the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> SNVs and the risk of developing MS in the Caucasian Spanish population."],"journal":["International journal of molecular sciences"],"pubmed_title":["Association between <i>LAG3/CD4</i> Genes Variants and Risk for Multiple Sclerosis."],"pmcid":["PMC9735634"],"funding_grant_id":["RETICS RD16/0006/0004 (ARADyAL)","IB20134","PI21/01683","GR21073","PI18/00540"],"pubmed_authors":["Garcia-Martin E","Garcia-Albea E","Benito-Leon J","Jimenez-Jimenez FJ","Calleja P","Millan-Pascual J","Turpin-Fenoll L","Alonso-Navarro H","Diaz-Sanchez M","Gomez-Tabales J","Agundez JAG","Plaza-Nieto JF"],"additional_accession":[]},"is_claimable":false,"name":"Association between <i>LAG3/CD4</i> Genes Variants and Risk for Multiple Sclerosis.","description":"Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between <i>LAG3</i> gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the <i>CD4</i> and <i>LAG3</i> genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> in 300 patients diagnosed with MS and 400 healthy patients using specific <i>TaqMan</i>-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the <i>HLADRB1*1501</i> genotype. The frequencies of the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and <i>HLADRB1*1501</i> genotype. The results of the current study showed a lack of association between the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> SNVs and the risk of developing MS in the Caucasian Spanish population.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:54.08Z","creation":"2025-04-04T08:00:54.08Z"},"accession":"S-EPMC9735634","cross_references":{"pubmed":["36499569"],"doi":["10.3390/ijms232315244"]}}