biostudies-literatureGarcia-Martin EFEDER fundsInstituto de Salud Carlos IIIJunta de Extremadura, Mérida, SpainFondo de Investigación Sanitaria, Instituto de Salud Carlos III, Madrid, Spain15244https://www.ebi.ac.uk/biostudies/studies/S-EPMC9735634biostudies-literatureUnknown23(23)Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between <i>LAG3</i> gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the <i>CD4</i> and <i>LAG3</i> genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> in 300 patients diagnosed with MS and 400 healthy patients using specific <i>TaqMan</i>-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the <i>HLADRB1*1501</i> genotype. The frequencies of the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and <i>HLADRB1*1501</i> genotype. The results of the current study showed a lack of association between the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> SNVs and the risk of developing MS in the Caucasian Spanish population.International journal of molecular sciencesAssociation between <i>LAG3/CD4</i> Genes Variants and Risk for Multiple Sclerosis.PMC9735634RETICS RD16/0006/0004 (ARADyAL)IB20134PI21/01683GR21073PI18/00540Garcia-Martin EGarcia-Albea EBenito-Leon JJimenez-Jimenez FJCalleja PMillan-Pascual JTurpin-Fenoll LAlonso-Navarro HDiaz-Sanchez MGomez-Tabales JAgundez JAGPlaza-Nieto JFfalseAssociation between <i>LAG3/CD4</i> Genes Variants and Risk for Multiple Sclerosis.Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between <i>LAG3</i> gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the <i>CD4</i> and <i>LAG3</i> genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> in 300 patients diagnosed with MS and 400 healthy patients using specific <i>TaqMan</i>-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the <i>HLADRB1*1501</i> genotype. The frequencies of the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and <i>HLADRB1*1501</i> genotype. The results of the current study showed a lack of association between the <i>CD4 rs1922452</i>, <i>CD4 rs951818</i>, and <i>LAG3 rs870849</i> SNVs and the risk of developing MS in the Caucasian Spanish population.2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:54.08Z2025-04-04T08:00:54.08ZS-EPMC97356343649956910.3390/ijms232315244