{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(23)"],"submitter":["Vasquez-Procopio J"],"pubmed_abstract":["Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108-30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy."],"journal":["International journal of molecular sciences"],"pagination":["15188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9735729"],"repository":["biostudies-literature"],"pubmed_title":["Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women."],"pmcid":["PMC9735729"],"pubmed_authors":["Tolentino-Dolores MC","Solis-Paredes M","Estrada-Gutierrez G","Torres-Torres J","Perichart-Perera O","Borboa-Olivares H","Sosa SEY","Vasquez-Procopio J","Marrufo-Gallegos KC","Martinez-Portilla RJ","Helguera-Repetto AC","Missirlis F"],"additional_accession":[]},"is_claimable":false,"name":"Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women.","description":"Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108-30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-20T03:32:48Z","creation":"2025-04-20T03:32:48Z"},"accession":"S-EPMC9735729","cross_references":{"pubmed":["36499537"],"doi":["10.3390/ijms232315188"]}}