{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amalraj J"],"funding":["Powered@NLHPC","Agencia Nacional de Investigación y Desarrollo"],"pagination":["15043"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9736124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(23)"],"pubmed_abstract":["The electrochemical behavior of N-methyl- and N-benzyl-4-piperidone curcumin analogs were studied experimentally and theoretically. The studied compounds present different substituents at the <i>para</i> position in the phenyl rings (-H, -Br, -Cl, -CF<sub>3</sub>, and -OCH<sub>3</sub>). We assessed their electrochemical behavior by differential pulse and cyclic voltammetry, while we employed density functional theory (DFT) M06 and M06-2x functionals along with 6-311+G(d,p) basis set calculations to study them theoretically. The results showed that compounds suffer a two-electron irreversible oxidation in the range of 0.72 to 0.86 V, with surface concentrations ranging from 1.72 × 10<sup>-7</sup> to 5.01 × 10<sup>-7</sup> mol/cm<sup>2</sup>. The results also suggested that the process is di"],"journal":["International journal of molecular sciences"],"pubmed_title":["Study of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach."],"pmcid":["PMC9736124"],"funding_grant_id":["ECM-02","ACT210097-ANID","Fondecyt 11170142","Fondecyt 1221874"],"pubmed_authors":["Amalraj J","Martinez-Cifuentes M","Monroy-Cardenas M","Vergara CE","Araya-Maturana R"],"additional_accession":[]},"is_claimable":false,"name":"Study of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach.","description":"The electrochemical behavior of N-methyl- and N-benzyl-4-piperidone curcumin analogs were studied experimentally and theoretically. The studied compounds present different substituents at the <i>para</i> position in the phenyl rings (-H, -Br, -Cl, -CF<sub>3</sub>, and -OCH<sub>3</sub>). We assessed their electrochemical behavior by differential pulse and cyclic voltammetry, while we employed density functional theory (DFT) M06 and M06-2x functionals along with 6-311+G(d,p) basis set calculations to study them theoretically. The results showed that compounds suffer a two-electron irreversible oxidation in the range of 0.72 to 0.86 V, with surface concentrations ranging from 1.72 × 10<sup>-7</sup> to 5.01 × 10<sup>-7</sup> mol/cm<sup>2</sup>. The results also suggested that the process is di","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-22T05:40:28.138Z","creation":"2025-04-05T21:25:51.875Z"},"accession":"S-EPMC9736124","cross_references":{"pubmed":["36499370"],"doi":["10.3390/ijms232315043"]}}