biostudies-literatureAmalraj JPowered@NLHPCAgencia Nacional de Investigación y Desarrollo15043https://www.ebi.ac.uk/biostudies/studies/S-EPMC9736124biostudies-literatureUnknown23(23)The electrochemical behavior of N-methyl- and N-benzyl-4-piperidone curcumin analogs were studied experimentally and theoretically. The studied compounds present different substituents at the <i>para</i> position in the phenyl rings (-H, -Br, -Cl, -CF₃, and -OCH₃). We assessed their electrochemical behavior by differential pulse and cyclic voltammetry, while we employed density functional theory (DFT) M06 and M06-2x functionals along with 6-311+G(d,p) basis set calculations to study them theoretically. The results showed that compounds suffer a two-electron irreversible oxidation in the range of 0.72 to 0.86 V, with surface concentrations ranging from 1.72 × 10^-7 to 5.01 × 10^-7 mol/cm². The results also suggested that the process is diInternational journal of molecular sciencesStudy of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach.PMC9736124ECM-02ACT210097-ANIDFondecyt 11170142Fondecyt 1221874Amalraj JMartinez-Cifuentes MMonroy-Cardenas MVergara CEAraya-Maturana RfalseStudy of the Electrochemical Behavior of N-Substituted-4-Piperidones Curcumin Analogs: A Combined Experimental and Theoretical Approach.The electrochemical behavior of N-methyl- and N-benzyl-4-piperidone curcumin analogs were studied experimentally and theoretically. The studied compounds present different substituents at the <i>para</i> position in the phenyl rings (-H, -Br, -Cl, -CF₃, and -OCH₃). We assessed their electrochemical behavior by differential pulse and cyclic voltammetry, while we employed density functional theory (DFT) M06 and M06-2x functionals along with 6-311+G(d,p) basis set calculations to study them theoretically. The results showed that compounds suffer a two-electron irreversible oxidation in the range of 0.72 to 0.86 V, with surface concentrations ranging from 1.72 × 10^-7 to 5.01 × 10^-7 mol/cm². The results also suggested that the process is di2022-01-01T00:00:00Z2022 Nov2025-04-22T05:40:28.138Z2025-04-05T21:25:51.875ZS-EPMC97361243649937010.3390/ijms232315043